Brain metastasis is the most common neurological complication of cancer and, in spite of the progress made with local (i.e., surgery and radiation) and systemic (i.e., targeted therapy, immunotherapy) therapies, prognosis remains poor. Indeed, the increased incidence of brain metastases is partially due to systemic therapies that work extra-cranially but do not provide the same therapeutic benefit in the brain. We study why and how cells from different cancer types (breast cancer, lung cancer, and melanoma) are able to access the brain, survive, and colonise this vital organ. We dissect the biology of these processes in vivo using experimental models and patient-derived material to challenge this unmet clinical need. Our research has identified novel brain metastasis mediators, characterised the metastasis-associated microenvironment, designed better experimental models, and explored novel methods to target brain metastasis as well as to prevent or revert the frequent impact of metastasis on brain function.
Publicaciones
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Hwang WL, Perrault EN, Birbrair A, Mattson BJ, Gutmann DH, Mabbott DJ, Cukierman E, Repasky EA, Sloan EK, Zong H, Demir IE, Saloman JL, Borniger JC, Hu J, Dietrich J, Breunig JJ, Çifcibaşı K, Ahmad Kasm KA, Valiente M, Wintermark M, Acharya MM, Scheff NN, D'Silva NJ, Vermeer PD, Wong RJ, Talbot S, Hervey-Jumper SL, Wang TC, Ye Y, Pan Y, Bunimovich YL, Amit M. (2024).Integrating priorities at the intersection of cancer and neuroscience. Cancer Cell (in press). Publicación CNIO.
Amit M, Anastasaki C, Dantzer R, Demir IE, Deneen B, Dixon KO, Egeblad M, Gibson EM, Hervey-Jumper SL, Hondermarck H, Magnon C, Monje M, Na'ara S, Pan Y, Repasky EA, Scheff NN, Sloan EK, Talbot S, Tracey KJ, Trotman LC, Valiente M, Van Aelst L, Venkataramani V, Venkatesh HS, Vermeer PD, Winkler F, Wong RJ, Gutmann DH, Borniger JC. (2024).Next Directions in the Neuroscience of Cancers Arising outside the CNS. Cancer Discovery 14, 669-673. Publicación CNIO.
Priego N, de Pablos-Aragoneses A, Perea-García M, Pieri V, Hernandez-Oliver C, Alvaro-Espinosa L, Rojas A, Sanchez O, Steindl A, Caleiras E, Garcia F, Garcia-Martin S, Grana-Castro O, Garcia-Mulero S, Serrano D, Velasco-Beltran P, Jimenez-Lasheras B, Egia-Mendikute L, Rupp L, Stammberger A, Meinhardt M, Chaachou-Charradi A, Martínez-Saez E, Bertero L, Cassoni P, Mangherini L, Pellerino A, Ruda R, Soffietti R, Al-Shahrour F, Saftig P, Sanz-Pamplona R, Schmitz M, Crocker SJ, Calvo A, Palazon A, Group R, Valiente M. (2024).TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells. Cancer Discovery (in press). Publicación CNIO.
Dankner M, Maritan SM, Priego N, Kruck G, Nkili-Meyong A, Nadaf J, Zhuang R, Annis MG, Zuo D, Nowakowski A, Biondini M, Kiepas A, Mourcos C, Le P, Charron F, Inglebert Y, Savage P, Théret L, Guiot MC, McKinney RA, Muller WJ, Park M, Valiente M, Petrecca K, Siegel PM. (2024).Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes. Neuro-Oncology 26, 1502-1066. Publicación CNIO.
Jagust P, Powell AM, Ola M, Watson L, de Pablos-Aragoneses A, García-Gómez P, Fallon R, Bane F, Heiland M, Morris G, Cavanagh B, McGrath J, Ottaviani D, Hegarty A, Cocchiglia S, Sweeney KJ, MacNally S, Brett FM, Cryan J, Beausang A, Morris P, Valiente M, Hill ADK, Varešlija D, Young LS (2024).RET overexpression leads to increased brain metastatic competency in luminal breast cancer.. J Natl Cancer I 116, 1632-1644. Publicación CNIO.
Cátia Monteiro, Lauritz Miarka, María Perea-García, Neibla Priego, Pedro García-Gómez , Laura Álvaro-Espinosa, Ana de Pablos-Aragoneses, Natalia Yebra, Diana Retana, Patricia Baena, Coral Fustero-Torre, Osvaldo Graña-Castro, Kevin Troulé, Eduardo Caleiras, Patricia Tezanos, Pablo Muela, Elisa Cintado , José Luis Trejo, Juan Manuel Sepúlveda , Pedro González-León , Luis Jiménez-Roldán , Luis Miguel Moreno , Olga Esteban , Ángel Pérez-Núñez, Aurelio Hernández-Lain, José Mazarico Gallego, Irene Ferrer, Rocío Suárez, Eva M. Garrido-Martín, Luis Paz-Ares, Celine Dalmasso, Elizabeth Cohen-Jonathan Moyal, Aurore Siegfried, Aisling Hegarty, Stephen Keelan, Damir Varešlija, Leonie S. Young, Malte Mohme, Yvonne Goy, Harriet Wikman, Jose Fernández-Alén, Guillermo Blasco, Lucía Alcázar, Clara Cabañuz, Sergei I. Grivennikov, Andrada Ianus , Noam Shemesh, Claudia C. Faria, Rebecca Lee , Paul Lorigan , Emilie Le Rhun, Michael Weller, Riccardo Soffietti, Luca Bertero , Umberto Ricardi, Joaquim Bosch-Barrera , Elia Sais, Eduard Teixidor, Alejandro Hernández-Martínez, Alfonso Calvo, Javier Aristu, Santiago M. Martin, Alvaro Gonzalez, Omer Adler, Neta Erez, RENACER* and Manuel Valiente (2022).Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. Nat Med 28, 752-765. Publicación CNIO. Open Access
Zhu L, Retana D, García-Gómez P, Álvaro-Espinosa L, Priego N, Masmudi-Martín M, Yebra N, Miarka L, Hernández-Encinas E, Blanco-Aparicio C, Martínez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodríguez-Perales S; RENACER, Soffietti R, Bertero L, Cassoni P, Weiss T, Muñoz J, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Laín A, Toldos O, Ruano Y, Alcázar L, Blasco G, Fernández-Alén J, Caleiras E, Lafarga M, Megías D, Graña-Castro O, Nör C, Taylor MD, Young LS, Varešlija D, Cosgrove N, Couch FJ, Cussó L, Desco M, Mouron S, Quintela-Fandino M, Weller M, Pastor J, Valiente M. (2022).A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. EMBO Mol Med 14, 14552. Publicación CNIO. Open Access
Zhu L, Retana D, García-Gómez P, Álvaro-Espinosa L, Priego N, Masmudi-Martín M, Yebra N, Miarka L, Hernández-Encinas E, Blanco-Aparicio C, Martínez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodríguez-Perales S, RENACER, Soffietti R, Bertero L, Cassoni P, Weiss T, Muñoz J, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez A, Hernández-Laín A, Toldos O, Ruano Y, Alcázar L, Blasco G, Fernández-Alén J, Caleiras E, Lafarga M, Megías D, Graña-Castro O, Nör C, Taylor MD, Young LS, Varešlija D, Cosgrove N, Couch FJ, Cussó L, Desco M, Weller M, Pastor J, Valiente M (2021).A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis. EMBO Mol Med (in press). Publicación CNIO.
Pisano F, Kashif MF, Balena A, Pisanello M, De Angelis F, de la Prida LM, Valiente M, D'Orazio A, De Vittorio M, Grande M, Pisanello F (2021).Plasmonics on a neural implant: engineering light-matter interactions on the nonplanar surface of tapered. Adv Opt Mater (in press). Publicación CNIO.
Pe?rez-Garci?a VM, Calvo GF, Bosque JJ, Leo?n-Triana O, Jime?nez J, Pe?rez- Beteta J, Belmonte-Beitia J, Valiente M, Zhu L, Garci?a-Go?mez P, Sa?nchez-Go?mez P, Herna?ndez-San Miguel E, Hortigu?ela R, Azimzade Y, Molina-Garci?a D, Marti?nez A, Acosta- Rojas A, Ortiz de Mendivil A, Valette F, Schucht P, Murek M, Pe?rez-Cano M, Albillo D, Honguero Marti?nez AF, Jime?nez London?o GA, Arana E, Garci?a Vicente AM (2020).Universal scaling laws rule explosive growth in human cancers.. Nat Phys 16, 1232-1237. Publicación CNIO. Open Access
Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massague J, Neman J, Sibson NR, Steeg PS, Thorsen F, Young LS, Varešlija D, Vultur A, Weis-Garcia F, Winkler F (2020).Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. Cancer Res 80, 4134-4323. Publicación CNIO. Open Access
Valiente M*, de la Prida* (2020).Breaking down the wall: the strategic plan of cancer to conquer the brain.. Epilepsy Curr (in press). Publicación CNIO.
Open Access