The Organ Crosstalk in Metabolic Diseases Group is dedicated to understanding how metabolic alterations and obesity trigger other secondary diseases such as cancer, diabetes, and cardiovascular diseases. Our research takes a holistic approach, aiming to comprehend how obesity disrupts the communication between organs. In this context, we have found that the activation in different organs of several stress kinases during obesity affects the development of tumours.
The Group focuses on four main aspects induced by obesity:
The alteration of adipose tissue and, consequently, the secretion of adipokines.
The onset of chronic inflammation, which is associated with an increased risk of cancer.
Cell metabolism alteration as a driver of disease.
The role of exercise in disease prevention and progression.
Publicaciones recientes
Cicuéndez B, Mora A, López JA, Curtabbi A, Pérez-García J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, Gómez-Santos B, Romero-Becerra R, Leiva M, Rodríguez E, León M, Leiva-Vega L, Gómez-Lado N, Torres JL, Hernández-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bolaños JP, Spinelli JB, Puigserver P, Enriquez JA, Vázquez J, Folgueira C, Sabio G. (2025).Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis. Nat Commun 16, 229. Publicación en otras instituciones.
Fernández-González I, Freire-Agulleiro O, Ferreira V, Silveira-Loureiro M, Rial-Pensado E, Garrido-Gil P, Martínez G, Rada P, Labandeira-García JL, Mittag J, González-García I, Diéguez C, Nogueiras R, Valverde ÁM, Davis RJ, Sabio G, Barca-Mayo O, López M. (2025).JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism. Mol Metab 98, . Publicación CNIO.
Folgueira C, Herrera-Melle L, López JA, Galvan-Alvarez V, Martin-Rincon M, Cuartero MI, García-Culebras A, Dumesic PA, Rodríguez E, Leiva-Vega L, León M, Porteiro B, Iglesias C, Torres JL, Hernández-Cosido L, Bonacasa C, Marcos M, Moro MÁ, Vázquez J, Calbet JAL, Spiegelman BM, Mora A, Sabio G. (2024).Remodeling p38 signaling in muscle controls locomotor activity via IL-15. Sci Adv 10, eadn5993. Publicación CNIO.
Rada P, Carceller-López E, Hitos AB, Gómez-Santos B, Fernández-Hernández C, Rey E, Pose-Utrilla J, García-Monzón C, González-Rodríguez Á, Sabio G, García A, Aspichueta P, Iglesias T, Valverde ÁM. (2024).Protein kinase D2 modulates hepatic insulin sensitivity in male mice. Mol Metab (in press). Publicación CNIO.
Herrera-Melle L, Cicuéndez B, López JA, Dumesic PA, Wilensky SE, Rodríguez E, Leiva-Vega L, Caballero A, León M, Vázquez J, Spiegelman BM, Folgueira C, Mora A, Sabio G. (2024).p38α kinase governs muscle strength through PGC1α in mice. Acta Physiol 240, e14234. Publicación CNIO.
Fondevila MF, Novoa E, Gonzalez-Rellan MJ, Fernandez U, Heras V, Porteiro B, Parracho T, Dorta V, Riobello C, da Silva Lima N, Seoane S, Garcia-Vence M, Chantada-Vazquez MP, Bravo SB, Senra A, Leiva M, Marcos M, Sabio G, Perez-Fernandez R, Dieguez C, Prevot V, Schwaninger M, Woodhoo A, Martinez-Chantar ML, Schwabe R, Cubero FJ, Varela-Rey M, Crespo J, Iruzubieta P, Nogueiras R. (2024).p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway. Cell Rep Med 5, 101401. Publicación en otras instituciones.
Santamans AM, Cicuéndez B, Mora A, Villalba-Orero M, Rajlic S, Crespo M, Vo P, Jerome M, Macías Á, López JA, Leiva M, Rocha SF, León M, Rodríguez E, Leiva L, Pintor Chocano A, García Lunar I, García-Álvarez A, Hernansanz-Agustín P, Peinado VI, Barberá JA, Ibañez B, Vázquez J, Spinelli JB, Daiber A, Oliver E, Sabio G. (2024).MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension. Sci Adv 10, eadk6524. Publicación en otras instituciones.
Goikoetxea-Usandizaga N, Bravo M, Egia-Mendikute L, Abecia L, Serrano-Maciá M, Urdinguio RG, Clos-García M, Rodríguez-Agudo R, Araujo-Legido R, López-Bermudo L, Delgado TC, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Peña-Cearra A, Simón J, Benedé-Ubieto R, Ariño S, Herranz JM, Azkargorta M, Salazar-Bermeo J, Martí N, Varela-Rey M, Falcón-Pérez JM, Lorenzo Ó, Nogueiras R, Elortza F, Nevzorova YA, Cubero FJ, Saura D, Martínez-Cruz LA, Sabio G, Palazón A, Sancho-Bru P, Elguezabal N, Fraga MF, Ávila MA, Bataller R, Marín JJG, Martín F, Martínez-Chantar ML. (2023).The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent. Hepatology 78, 878-895. Publicación en otras instituciones.
Sáenz de Urturi D, Buqué X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fernández E, Olaizola P, Gómez-Santos B, Apodaka-Biguri M, González-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, García-Rodríguez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Martín-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Martínez-Chantar ML, Nogueiras R, Aspichueta P. (2022).Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis. Nat Commun 13, 1096. Publicación en otras instituciones.
Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. (2022).Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Biochem Bioph Res Co 612, 119-125. Publicación en otras instituciones.
Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. (2022).Targeting ERK3/MK5 complex for treatment of obesity and diabetes.. Biochem Bioph Res Co 612, 119-125. Publicación en otras instituciones.
Pena-Leon V, Folgueira C, Barja-Fernández S, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R, Seoane LM. (2022).Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nat Metabolism 4, 901-917. Publicación en otras instituciones.
