Grupo de Carcinogénesis Epitelial

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología de Tumores | Grupo de Carcinogénesis Epitelial

Francisco Real
Francisco Real Jefe de Grupo
T +34 917328000 (Ext 3660)
freal@cnio.es

Investigadores Científicos

  • Miriam Marqués

Becarios Post-doctorales

  • Mikhail Chesnokov
  • Alejandro Da Silva
  • Irene Felipe
  • Eleonora Lapi
  • Jaime Martínez de Villarreal

Becarios Pre-Doctorales

  • Santiago Domingo Barber
  • Catalina Berca
  • Shidong Deng
  • Sarah Klauß
  • Chengsi Wu

Técnicos de Laboratorio

  • Ruth Josefina Micha
  • Leticia Rodríguez

Científico Visitante

  • Luis César Fernández
  • Mark Kalisz
  • Gabriel Piedrafita

We focus on the molecular pathophysiology of pancreatic ductal adenocarcinoma (PDAC) and bladder carcinoma taking a disease-oriented approach. These tumours present very distinct clinical challenges. We learn from patient samples, cultured cells/organoids, and genetically modified mice. To translate the findings, we bring this knowledge to a “population” level – leveraging on information and samples from large patient cohorts – together with Núria Malats (CNIO).

PDAC has a dismal prognosis even when diagnosed early. We aim at dissecting the molecular mechanisms involved in very early steps of tumour development, harnessing the power of mouse genetic editing. A main hypothesis is that cell differentiation is an early and potent tumour suppressor mechanism. Understanding the contribution of early molecular events is crucial to design better strategies for prevention and early tumour detection.

Bladder cancer presents with a very wide clinical and pathological heterogeneity. We aim at acquiring knowledge about the underlying biology that might be leveraged towards improved tumour subclassification, prediction of outcome, and therapy.

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