Our research focuses on a protein complex named cohesin that embraces DNA to mediate sister chromatid cohesion, a process essential for chromosome segregation and faithful DNA repair by homologous recombination. Cohesin also plays a major role in the spatial organisation of the genome by promoting long-range DNA looping, which in turn contributes to transcriptional regulation. Mutations in cohesin have been found in several tumour types, most prominently in bladder cancer, Ewing sarcoma and acute myeloid leukaemia. Germline mutations in cohesin and its regulatory factors are also at the origin of human developmental syndromes collectively known as cohesinopathies.
Our goal is to understand how cohesin works, how it is regulated, and how its dysfunction contributes to cancer and other human diseases. In particular, we are intrigued by the existence of different versions of the cohesin complex. We use human cells and mouse models carrying knock out alleles of genes encoding variant cohesin subunits to investigate their functional specificity.
SELECT dxsjj_posts.*
FROM dxsjj_posts LEFT JOIN dxsjj_postmeta ON ( dxsjj_posts.ID = dxsjj_postmeta.post_id ) LEFT JOIN dxsjj_postmeta AS mt1 ON ( dxsjj_posts.ID = mt1.post_id AND mt1.meta_key = 'factor_impacto' ) LEFT JOIN dxsjj_postmeta AS mt2 ON ( dxsjj_posts.ID = mt2.post_id ) LEFT JOIN dxsjj_postmeta AS mt3 ON ( dxsjj_posts.ID = mt3.post_id ) LEFT JOIN dxsjj_postmeta AS mt4 ON ( dxsjj_posts.ID = mt4.post_id )
WHERE 1=1 AND (
(
dxsjj_postmeta.meta_key = 'factor_impacto'
OR
mt1.post_id IS NULL
)
AND
mt2.meta_key = 'autores'
AND
( mt3.meta_key = 'id_grupos' AND mt3.meta_value LIKE '{3b8a55338e8c97a9d45df414912058b0b3cfe3a92b3ebec9be7b6bef1772b0fb}50004263{3b8a55338e8c97a9d45df414912058b0b3cfe3a92b3ebec9be7b6bef1772b0fb}' )
AND
( mt4.meta_key = 'anyo' AND CAST(mt4.meta_value AS SIGNED) >= '2020' )
) AND dxsjj_posts.post_type = 'cnio_publication' AND ((dxsjj_posts.post_status = 'publish'))
GROUP BY dxsjj_posts.ID
ORDER BY CAST(mt4.meta_value AS SIGNED) DESC, CAST(dxsjj_postmeta.meta_value AS SIGNED) DESC, CAST(mt2.meta_value AS CHAR) ASC
González-Martínez J, Sánchez-Belmonte A, Ayala E, García A, Nogueira E, Muñoz J, Melati A, Giménez D, Losada A, Ortega S, Malumbres M (2024).miR-203 controls developmental timing and early fate restriction during preimplantation embryogenesis.. BioRxiv (in press). Publicación CNIO. More Info
López de Alba E, Salguero I, Giménez-Llorente D, Fernández-Sanromán Á, Casajús-Pelegay E, Terrón-Bautista J, Barroso-González J, Bernal JA, Macintyre G, Fernández-Leiro R, Losada A, Cortés-Ledesma F (2024).A comprehensive genetic catalog of human double-strand break repair.. BioRxiv (in press). Publicación CNIO. More Info
Villarroya-Beltri C, Martins AFB, García A, Giménez D, Zarzuela E, Novo M, Del Álamo C, González-Martínez J, Bonel-Pérez GC, Díaz I, Guillamot M, Chiesa M, Losada A, Graña-Castro O, Rovira M, Muñoz J, Salazar-Roa M, Malumbres M. (2022).Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.. EMBO J 42, e111251. Publicación CNIO.
Alonso-Gil D, Cuadrado A, Giménez-Llorente D, Rodríguez-Corsino M, Losada A (2022).Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. bioRxiv (in press). Publicación CNIO. Open Access
Ruiz-Pinto S, Pita G, Martín M, Nunez-Torres R, Cuadrado A, Shahbazi MN, Caronia D, Kojic A, Moreno LT, de la Torre-Montero JC, Lozano M, López-Fernández LA, Ribelles N, García-Saenz JA, Alba E, Milne RL, Losada A, Pérez-Moreno M, Benítez J, González-Neira A (2021).Regulatory CDH4 genetic variants associate with risk to develop capecitabine-induced hand-foot syndrome.. Clin Pharmacol Ther 109, 462-470. Publicación CNIO.
Open Access