Our laboratory, in collaboration with Lilly, works on the identification and validation of cellular models of chromosomal instability (CIN) and novel dependencies as a result of CIN. We apply bespoke functional genomic screens to uncover novel vulnerabilities, in combination with in vitro and in vivo approaches, to obtain a complete understanding of the role of CIN in tumour development and anti-tumour response. Each potential target undergoes a validation process using xenografts, allografts, and mouse models developed at the CNIO. Our work includes the use of non-invasive in vivo imaging technologies and histochemical characterisation of tumours, using a variety of intrinsic and extrinsic tumour markers. The final step is validation in human samples using tumour tissue arrays.
Investigadores Científicos
- Roberto Gómez
- Sonia Hernández
- Eva Pilar Lospitao
- Carolina Maestre
- Gloria Martínez del Hoyo
Técnicos de Laboratorio
- Jenniffer Patricia Condo
- Laura Diezma
- Alicia Luengo
- Sandra Peregrina
- María Jesús Valle
Publicaciones recientes
- (2010). SIRT1 contributes to telomere maintenance and augments global homologous recombination.. J Cell Biol 191, 1299-1313. Publicación CNIO.
- (2008). Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.. Proc Natl Acad Sci USA 105, 11400-11405. Publicación CNIO.
- (2004). The Rgr Oncogene Induces Tumorigenesis in Transgenic Mice.. Cancer Res 64, 6041-6049. Publicación CNIO.
- (2000). Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).. Mol Cell Biol 20, 2915-2925. Publicación CNIO.
- (2005). A Mouse p10, an alternative spliced form of p15INK4b,inhibits cell cycle progression and malignant transformation.. Cancer Res 65, 3249-3526. Publicación CNIO.