Grupo de Inmunidad del Cáncer

Inicio | Investigación e innovación | Programas Científicos | Programa de Oncología Molecular | Grupo de Inmunidad del Cáncer

María Casanova

Investigadores Científicos

  • Alba de Juan

Becarios Post-doctorales

  • Sarai Martínez

Becarios Pre-Doctorales

  • Eduardo Garvín
  • Jan Hochstadt
  • Mariola Munárriz

Técnicos de Laboratorio

  • David Cáceres
  • Mónica Gómez
  • María Nogales

The Cancer Immunity lab studies myeloid cells in the different tumour microenvironments. By focusing on the remarkable heterogeneity of these cells in a tissue-based manner, we aim to uncover their functional roles in shaping T cell responses.

First, we focus on how myeloid training can impact long-term anti-tumour responses. Next, we study how resident macrophages in the lung and in the ovary shape tumour-associated fibroblasts and metabolic responses, respectively. Lastly, we analyse how circadian biology impacts the initiation, progression and unresponsiveness to current therapies in lung cancer.

Publicaciones

    SELECT dxsjj_posts.* FROM dxsjj_posts LEFT JOIN dxsjj_postmeta ON ( dxsjj_posts.ID = dxsjj_postmeta.post_id ) LEFT JOIN dxsjj_postmeta AS mt1 ON ( dxsjj_posts.ID = mt1.post_id AND mt1.meta_key = 'factor_impacto' ) LEFT JOIN dxsjj_postmeta AS mt2 ON ( dxsjj_posts.ID = mt2.post_id ) LEFT JOIN dxsjj_postmeta AS mt3 ON ( dxsjj_posts.ID = mt3.post_id ) LEFT JOIN dxsjj_postmeta AS mt4 ON ( dxsjj_posts.ID = mt4.post_id ) WHERE 1=1 AND ( ( dxsjj_postmeta.meta_key = 'factor_impacto' OR mt1.post_id IS NULL ) AND mt2.meta_key = 'autores' AND ( mt3.meta_key = 'id_grupos' AND mt3.meta_value LIKE '{4bb32fa021e2267e9cb628fcfb8e571a932c1c96278648821bd8d71d561c1181}50011571{4bb32fa021e2267e9cb628fcfb8e571a932c1c96278648821bd8d71d561c1181}' ) AND ( mt4.meta_key = 'anyo' AND CAST(mt4.meta_value AS SIGNED) >= '2019' ) ) AND dxsjj_posts.post_type = 'cnio_publication' AND ((dxsjj_posts.post_status = 'publish')) GROUP BY dxsjj_posts.ID ORDER BY CAST(mt4.meta_value AS SIGNED) DESC, CAST(dxsjj_postmeta.meta_value AS SIGNED) DESC, CAST(mt2.meta_value AS CHAR) ASC

  • Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M (2023). TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792-801. Publicación CNIO.
  • Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Le Berichel J, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H (2022). Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discovery 12, 2606-2625. Publicación CNIO.
  • Casanova-Acebes, M., Dalla, E., Leader, A.M, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Chober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch, Aguirre-Ghiso JA, Merad M (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578-584. Publicación en otras instituciones.
  • Hidalgo A , Casanova-Acebes M (2021). Dimensions of neutrophil life and fate. Semin Immunol (in press). Publicación CNIO.
  • Casanova-Acebes M, Menéndez-Gutiérrez MP, Porcuna J, Álvarez-Errico D, Lavin Y, García A, Kobayashi S, Le Berichel J, Núñez V, Were F, Jiménez-Carretero D, Sánchez-Cabo F, Merad M, Ricote M (2020). RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.. Nat Commun 11, 1655. Publicación en otras instituciones.

Subir