“Este contenido se encuentra unicamente en inglés”
- Aleida Pujol
Técnicos de Laboratorio
- Estefania Ayala
- Carmen Gómez
- Jaime Muñoz
- Patricia Prieto
- Pierfrancesco Vargiu
The laboratory mouse is the experimental model of choice for genetic studies and preclinical drug development in cancer. The Transgenic Mice Unit is dedicated to the genetic edition of the mouse germ line and to the generation of genetically modified mouse strains. Hundreds of mouse genes have been specifically modified at our Unit. In many cases, these modifications reproduce the genetic alterations found in human cancers and are introduced in the mouse to generate preclinical models of the disease, thereby contributing to the development of more efficient targeted therapies. In other instances, genetically modified mice are created for testing hypothesis in vivo, in a physiological context, with the aim of gaining new insight into the molecular mechanisms responsible for converting a normal cell into a malignant cell or for making a tumour grow and expand and subsequently invade other organs and become deadly. Cancer is an extremely complex disease that cannot be sufficiently studied in a tissue culture plate. The generation of genetically modified mice is one of the basic pillars on which cancer research at the CNIO is based.
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Cell Reports 22, 396-410.
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Nat Commun 9, 4795-.
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Nature 546, 676-680.
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Cell Reports 19, 928-938.
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Proc Natl Acad Sci USA 114, 9367-9372.
- Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations.(2016)
Nat Communications 7, 11739-.
- A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.(2016)
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Cell Cycle 14, 3897-3907.
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Cell Reports (in press).
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Stem Cell Reports 2, 690-706.
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Nat Communications 5, 4226-.
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Nat Communications 4, 1946-.
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PLoS Genet 9, e1003261-.