Molecular Imaging enables the visualisation of cellular function and the follow-up of the molecular processes in living organisms without perturbing them. Molecular imaging offers significant advantages to the scientist over traditional research paradigms. While traditional studies of tumour response to a therapeutic agent involve a large cohort of animals analysed at multiple time points, molecular imaging allows characterisation of tumour development and response to a therapy within the same small set of animals imaged longitudinally at multiple time points. This reduces the number of mice used and increases the statistical power of the study because each animal serves as its own control. Other advantages include the ability to interrogate the whole body, and to visualise the molecular target of interest in 3-dimensional space. Finally, molecular imaging is becoming a key bridging technology for the translation of experimental preclinical findings into the clinical environment and, currently, with the theranostic strategy, we can treat the tumours with the same molecule used for PET visualisation by simply changing the isotope for the beta emitter pair.

Técnicos de Laboratorio
- Guillermo Garaulet
- Guillermo Medrano
- Judith Rey
Publicaciones
- (2022). Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division. Cell Death Differ 29, 1474-1485. Publicación CNIO.
- (2022). Versatile Near-Infrared Super-Resolution Imaging of Amyloid Fibrils with the Fluorogenic Probe CRANAD-2. Chem-Eur J 28, e202200026. Publicación CNIO.
- (2022). Clickable Albumin Nanoparticles for Pretargeted Drug Delivery toward PD-L1 Overexpressing Tumors in Combination Immunotherapy. Bioconjugate Chem 33, 821-828. Publicación CNIO.
- (2022). Development of anti-membrane type 1-matrix metalloproteinase nanobodies as immunoPET probes for triple negative breast cancer imaging. Front Med 24, 1058455. Publicación CNIO.
- (2021). Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Nat Commun 12, 5343. Publicación CNIO.
Open Access
- (2021). Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nat Commun 12, 3660. Publicación CNIO.
Open Access
- (2021). A New Antifungal-Loaded Sol-Gel Can Prevent Candida albicans Prosthetic Joint Infection. Antibiotics-Basel 10, 711. Publicación CNIO.
- (2021). Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles. Adv Sci 8, e2101107. Publicación CNIO.
- (2021). Current Landscape of Imaging and the Potential Role for Artificial Intelligence in the Management of COVID-19. Curr Probl Diagn Radiol 50, 430-435. Publicación CNIO.
- (2020). Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer.. Clin Cancer Res 26, 35-45. Publicación CNIO.
- (2020). A new antibiotic-loaded sol-gel can prevent bacterial prosthetic joint infection: from in vitro studies to an in vivo model.. Front Microbiol 17, 2935. Publicación CNIO.
- (2020). Beneficial effects of manually assisted chiropractic adjusting instrument in a rabbit model of osteoarthritis. Sci Rep 10, 1237. Publicación CNIO.
Open Access
- (2020). Current landscape of imaging and the potential role for artificial intelligence in the management of COVID-19.. Curr Probl Diagn Radiol (in press). Publicación CNIO.
- (2019). Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer Cell 35, 573-587. Publicación CNIO.
- (2019). Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Cancer Gene Ther 26, 216-233. Publicación CNIO.
- (2019). Effects of a Ketogenic Diet on [18F]FDG-PET Imaging in a Mouse Model of Lung Cancer. Mol Imaging Biol 21, 279-285. Publicación CNIO.
- (2018). FGF21 gene therapy as treatment for obesity and insulin resistance. EMBO Mol Med 10, e8791. Publicación CNIO.
Open Access
- (2018). A versatile drug delivery system targeting senescent cells. EMBO Mol Med 10, pii: e9355. Publicación CNIO.
Open Access
- (2018). Role of Activator Protein-1 Complex on the Phenotype of Human Osteosarcomas Generated from Mesenchymal Stem Cells. Stem Cells 36, 1487-1500. Publicación CNIO.
- (2018). Effects of a Ketogenic Diet on [18F]FDG-PET Imaging in a Mouse Model of Lung Cancer. Mol Imaging Biol 21, 279-285. Publicación CNIO.
- (2018). MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management. Contrast Media & Molecular Imaging 2018, 8382148. Publicación CNIO.
Open Access