Unidad de Imagen Molecular

Francisca Mulero Jefe de Unidad
T +34 917328000 (Ext 3150)
fmulero@cnio.es

Becarios Post-doctorales

Bárbara Beatriz Báez

Técnicos de Laboratorio

Guillermo Garaulet
Guillermo Medrano

Molecular imaging is a medical imaging modality that enables the visualisation, characterisation, and measurement of biological processes at the molecular and cellular levels within living organisms. This field of medical imaging combines principles from various disciplines, including chemistry, biology, physics, and imaging technology, to provide detailed information about the biochemical and physiological processes occurring in tissues and organs. Preclinical molecular imaging techniques are non-invasive, meaning they do not require the sacrifice or dissection of animals. This allows for longitudinal studies where researchers can monitor disease progression and treatment effects over time in the same animals.

The Molecular Imaging Unit provides the CNIO Research Groups with a range of advanced equipment and technologies that can be instrumental in early disease detection, monitoring disease progression, assessing the effectiveness of treatments, and gaining a deeper understanding of disease mechanisms at the molecular level. This support is crucial for advancing medical research and improving patient care.

Publicaciones

Baudin J, Hernandez-Baixauli J, Romero-Giménez J, Yang H, Mulero F, Puiggròs F, Mardinoglu A, Arola L, Caimari A. (2024). A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats. Biomed Pharmacother 179, 117326. Publicación CNIO.
Baudin J, Hernandez-Baixauli J, Quesada-Vázquez S, Mulero F, Puiggròs F, Arola L, Caimari A. (2024). Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats. Food Funct. 15, 4905-4924. Publicación CNIO.
Magro N, Oteo M, Romero E, Ibáñez-Moragues M, Lujan VM, Martínez L, Vela O, López-Melero ME, Arroyo AG, Garaulet G, Martínez-Torrecuadrada JL, Mulero F, Morcillo MA. (2024). Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy. Nucl Med Biol (in press). Publicación CNIO.
Salmón M, Álvarez-Díaz R, Fustero-Torre C, Brehey O, Lechuga CG, Sanclemente M, Fernández-García F, López-García A, Martín-Guijarro MC, Rodríguez-Perales S, Bousquet-Mur E, Morales-Cacho L, Mulero F, Al-Shahrour F, Martínez L, Domínguez O, Caleiras E, Ortega S, Guerra C, Musteanu M, Drosten M, Barbacid M. (2023). Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas.. J Clin Invest 133, e164413. Publicación CNIO. Open Access
Martínez-Illescas NG, Leal S, González P, Graña-Castro O, Muñoz-Oliveira JJ, Cortés-Peña A, Gómez-Gil M, Vega Z, Neva V, Romero A, Quintela-Fandino M, Ciruelos E, Sanz C, Aragón S, Sotolongo L, Jiménez S, Caleiras E, Mulero F, Sánchez C, Malumbres M, Salazar-Roa M (2023). miR-203 drives breast cancer cell differentiation. Breast Cancer Res 25, 91. Publicación CNIO. Open Access
Mulero F (2023). Editorial: ImmunoPET imaging in disease diagnosis and therapy assessment.. Front Med 10, 1231525. Publicación CNIO. Open Access
González-Martínez J, Cwetsch AW, Gilabert-Juan J, Gómez J, Garaulet G, Schneider P, de Cárcer G, Mulero F, Caleiras E, Megías D, Porlan E, Malumbres M. (2022). Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division. Cell Death Differ 29, 1474-1485. Publicación CNIO.
Torra J, Viela F, Megías D, Sot B, Flors C (2022). Versatile Near-Infrared Super-Resolution Imaging of Amyloid Fibrils with the Fluorogenic Probe CRANAD-2. Chem-Eur J 28, e202200026. Publicación CNIO.
Gerke C, Zabala Gutierrez I, Méndez-González D, Cruz MCI, Mulero F, Jaque D, Rubio-Retama J (2022). Clickable Albumin Nanoparticles for Pretargeted Drug Delivery toward PD-L1 Overexpressing Tumors in Combination Immunotherapy. Bioconjugate Chem 33, 821-828. Publicación CNIO.
Mulero F, Oteo M, Garaulet G, Magro N, Rebollo L, Medrano G, Santiveri C, Romero E, Sellek RE, Margolles Y, Campos-Olivas R, Arroyo AG, Fernández LA, Morcillo MA, Martínez-Torrecuadrada JL (2022). Development of anti-membrane type 1-matrix metalloproteinase nanobodies as immunoPET probes for triple negative breast cancer imaging. Front Med 24, 1058455. Publicación CNIO. Open Access
Bertolin J, Sánchez V, Ribera A, Jaén ML, Garcia M, Pujol A, Sánchez X, Muñoz S, Marcó S, Pérez J, Elias G, León X, Roca C, Jimenez V, Otaegui P, Mulero F, Navarro M, Ruberte J, Bosch F. (2021). Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Nat Commun 12, 5343. Publicación CNIO. Open Access
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A (2021). Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nat Commun 12, 3660. Publicación CNIO. Open Access
Garlito-Díaz H, Esteban J, Mediero A, Carias-Cálix RA, Toirac B, Mulero F, Faus-Rodrigo V, Jiménez-Morales A, Calvo E, Aguilera-Correa JJ. (2021). A New Antifungal-Loaded Sol-Gel Can Prevent Candida albicans Prosthetic Joint Infection. Antibiotics-Basel 10, 711. Publicación CNIO.
Mora-Raimundo P, Lozano D, Benito M, Mulero F, Manzano M, Vallet-Regí M. (2021). Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles. Adv Sci 8, e2101107. Publicación CNIO.
Shaikh F, Andersen MB, Sohail MR, Mulero F, Awan O, Dupont-Roettger D, Kubassova O, Dehmeshki J, Bisdas S (2021). Current Landscape of Imaging and the Potential Role for Artificial Intelligence in the Management of COVID-19. Curr Probl Diagn Radiol 50, 430-435. Publicación CNIO.
Quintela-Fandino M, Morales S, Cortés-Salgado A, Manso L, Apala JV, Muñoz M, Gasol Cudos A, Salla Fortuny J, Gion M, Lopez-Alonso A, Cortés J, Guerra J, Malón D, Caleiras E, Mulero F, Mouron S (2020). Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer.. Clin Cancer Res 26, 35-45. Publicación CNIO.
Aguilera-Correa JJ, Garcia-Casas A, Mediero A, Romera D, Mulero F, Cuevas-López I, Jiménez-Morales A, Esteban J (2020). A new antibiotic-loaded sol-gel can prevent bacterial prosthetic joint infection: from in vitro studies to an in vivo model.. Front Microbiol 17, 2935. Publicación CNIO.
Conesa-Buendía FM, Mediero A, Fujikawa R, Esbrit P, Mulero F, Mahillo-Fernández I, Mues AO (2020). Beneficial effects of manually assisted chiropractic adjusting instrument in a rabbit model of osteoarthritis. Sci Rep 10, 1237. Publicación CNIO. Open Access
Shaikh F, Andersen MB, Sohail MR, Mulero F, Awan O, Dupont-Roettger D, Kubassova O, Dehmeshki J, Bisdas S (2020). Current landscape of imaging and the potential role for artificial intelligence in the management of COVID-19.. Curr Probl Diagn Radiol (in press). Publicación CNIO.
Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li Jing, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob Harrys KC, Cabras L, Mustenau M, Drosten M, Ortega S, Mulero F, Sainz B, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Hidalgo M, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M (2019). Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer Cell 35, 573-587. Publicación CNIO.
Garaulet G, Pérez-Chacon G, Alarcón H, Alfranca A, Mulero F, Martínez-Torrecuadrada J, Zapata JM, Rodríguez A (2019). Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Cancer Gene Ther 26, 216-233. Publicación CNIO.
Cussó L, Musteanu M, Mulero F, Barbacid M, Desco M (2019). Effects of a Ketogenic Diet on [18F]FDG-PET Imaging in a Mouse Model of Lung Cancer. Mol Imaging Biol 21, 279-285. Publicación CNIO.