Unidad de Espectroscopía y RMN

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Técnicos de Laboratorio

  • Clara María Santiveri

This Unit focuses on the technical and scientific management of Nuclear Magnetic Resonance (NMR) Spectroscopy and molecular biophysics instrumentation available at the Structural Biology Programme. It provides CNIO researchers with equipment and experimental support for a variety of techniques used in biophysical studies of molecules involved in cancer. This includes the in vitro characterisation of the structure and dynamics of proteins by NMR, and characterisation of the affinity and kinetics of the interactions of proteins with other biopolymers and small molecules that could represent initial hits in the drug discovery process, or serve as research compounds for biophysical and functional studies. Furthermore, we use NMR to characterise the metabolic profiles of biofluids, cell growth media, and cell and tissue extracts from both animal models of cancer and human samples. In addition, in 2020, we adopted a mass spectrometer for the characterisation of intact proteins and for metabolite studies using HPLC-MS methods.