In the Computational Oncology Group, we are tackling some of the deadliest cancers by targeting the causes of chromosomal instability (CIN). By therapeutically targeting CIN, we aim to improve patient outcomes.
Our main research areas include:
- Using model systems to develop therapeutic strategies to target CIN.
- Predicting therapy response using CIN signatures in patient biopsies.
- Developing single cell sequencing approaches for ultrasensitive CIN detection.
We aim to apply these technologies at the earliest stages of tumour development in patients with premalignant lesions, with the goal of preventing aggressive, difficult to treat cancers.