Cancer is a complex disease whereby cells grow and reproduce uncontrollably. One important feature necessary to understand cancer is its heterogeneity, which indicates that the effect of alterations could be different depending on the cellular context. In the Computational Cancer Genomics (CCG) Lab, we aim to understand the context-dependent cancer fitness landscape both by applying a computational approach and by setting up experimental collaborations. For example, we are specifically interested in changing the cancer fitness landscape depending on time, by analysing the associations between germline variants and somatic alterations, or by comparing the differences between the primary tumour and metastasis. In addition, we aim to further pursue how protein-protein interaction networks of cancer driver genes can be perturbed by their somatic or germline variants. We expect that our context-dependent cancer fitness landscape will provide a crucial direction for personalised medicine, since we are aiming to address the heterogeneity across patients, conditions, and cellular contexts.
Becarios Pre-Doctorales
- Jaejun Lee
Técnicos de Laboratorio
- Adrián Maqueda
- Manuel Moradiellos
Publicaciones
- (2023). Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma. J Transl Med 21, 730. Publicación CNIO.
- (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
- (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
- (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.. Nat Commun 12, 7051. Publicación CNIO.
Open Access - (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. Publicación CNIO.
- (2019). Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer.. Cancers 11, E362. Publicación en otras instituciones.
- (2018). Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.. Nat Commun 9, 2601. Publicación en otras instituciones.
