Grupo de Genómica Computacional del Cáncer

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología Estructural | Grupo de Genómica Computacional del Cáncer

Solip Park

Técnicos de Laboratorio

  • Manuel Moradiellos

Cancer is one of the most complex human diseases, involving genetic, environmental, and even unknown factors. Over the past several decades, our knowledge of cancer has rapidly accumulated thanks to different omics technologies, including genomics and proteomics. However, we still lack a complete understanding of the cancer fitness landscape across conditions. For example, how do cancer genes change their working models of tumour progression depending on cancer types or contexts? What kind of trans-interactions exist between 2 genes or many genes beyond single-gene level alterations? How can protein complexes or interactions be perturbed depending on different mutation positions? Based on large-scale genomics and proteomics analyses, we aim to pursue these questions.

Publicaciones

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  • Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
  • Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
  • Park S, Supek F, Lehner B (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.. Nat Commun 12, 7051. Publicación CNIO. Open Access Open Access
  • Herranz-Montoya I, Park S, Djouder N (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. Publicación CNIO.
  • Díaz-Gay M, Franch-Expósito S, Arnau-Collell C, Park S, Supek F, Muñoz J, Bonjoch L, Gratacós-Mulleras A, Sánchez-Rojas PA, Esteban-Jurado C, Ocaña T, Cuatrecasas M, Vila-Casadesús M, Lozano JJ, Parra G, Laurie S, Beltran S, Consortium E, Castells A, Bujanda L, Cubiella J, Balaguer F, Castellví-Bel S. (2019). Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer.. Cancers 11, E362. Publicación en otras instituciones.
  • Park S, Supek F, Lehner B (2018). Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.. Nat Commun 9, 2601. Publicación en otras instituciones.

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