Grupo de Genómica Computacional del Cáncer

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología Estructural | Grupo de Genómica Computacional del Cáncer

Solip Park

Becarios Post-doctorales

  • Seokjin Ham
  • A-Reum Nam

Becarios Pre-Doctorales

  • Jaejun Lee
  • Adrián Maqueda
  • Manuel Moradiellos
  • Ana María Sartorius

Cancer is a multifaceted disease influenced by multiple factors. Moreover, the impact of genomic alterations varies considerably depending on the cellular context. In the Computational Cancer Genomics Lab, we strive to decipher the context-dependent cancer fitness landscape. We do this by identifying novel cancer predisposition genes (CPGs), measuring variations in cancer fitness across cancer states, and constructing dynamic protein-protein interaction networks. Our research is rooted in cancer genomics, systems biology, and network medicine. First, our findings aim to provide a comprehensive understanding of tumour progression via novel CPGs. Second, after examining 250,000 primary and metastatic samples, we discerned specific cancer types/cancer genes with distinct fitness levels based on their cancer states. Through extensive data analysis, our goal is to address core questions in cancer genetics and to explore the practical and clinical implications of our genomic findings.

Publicaciones

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  • Herranz-Montoya I, Angulo-Aguado M, Perna C, Zagorac S, García-Jimeno L, Park S, Djouder N. (2025). p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer. Nat Commun 16, 3934. Publicación CNIO.
  • Song S, Koh Y, Kim S, Lee SM, Kim HU, Ko JM, Lee SH, Yoon SS, Park S (2023). Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes.. Genome Med 15, 107. Publicación CNIO.
  • Koh Y, Kim H, Joo SY, Song S, Choi YH, Kim HR, Moon B, Byun J, Hong J, Shin DY, Park S, Lee KH, Lee KT, Lee JK, Park D, Lee SH, Jang JY, Lee H, Kim JA, Yoon SS, Park JK. (2023). Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma. J Transl Med 21, 730. Publicación CNIO.
  • Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
  • Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. Publicación CNIO.
  • Park S, Supek F, Lehner B (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.. Nat Commun 12, 7051. Publicación CNIO. Open Access Open Access
  • Herranz-Montoya I, Park S, Djouder N (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. Publicación CNIO. Open Access Open Access

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