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CNIO Publications, Year 2018

A gene that increases the risk of pancreatic cancer controls inflammation in normal tissue

Nature

A gene that increases the risk of pancreatic cancer controls inflammation in normal tissue

Madrid, 14 February, 2018

Inflammation is a defensive response of the body to aggression, but when it persists it can be harmful and can even predispose the subject to cancer. Hence, it is crucial to understand fully the relationship between inflammation and cancer. A group of researchers at the Spanish National Cancer Research Centre (CNIO) has now discovered an unexpected link between the two processes: in the pancreas, one of the genes that increases the risk of developing pancreatic cancer also controls...

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PNAS

CNIO researchers discover a potential new therapeutic strategy for pancreatic cancer

Madrid, 1 February, 2018

In most pancreatic cancer patients, the diagnosis is made when the disease is already advanced, and there is no effective treatment at present. There have been no significant advances to combat it in recent decades and unfortunately, its occurrence is on the increase. Now, a group of researchers from the Spanish National Cancer Research Centre (CNIO) may have found a new form of attack. “This tumour is so aggressive and so complex that it is necessary to try and attack it from various...

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Paula Martínez (left) and Maria A. Blasco (right), first authors or the paper./ CNIO

eLife

CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres

Madrid, 30 January, 2018

Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) has succeeded in curing this disease in mice using a gene therapy that lengthens the telomeres. Their work constitutes a "proof of concept that telomerase activation represents an effective treatment against pulmonary fibrosis," the authors write in...

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c-Raf ablation induces the regression of advanced lung tumours in mice

Cancer Cell

A new strategy induces the regression of advanced lung tumours in mice

Madrid, 25 January, 2018

A study published in Cancer Cell by researchers from the Molecular Oncology Programme at the Spanish National Cancer Research Centre (CNIO) shows how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours in a genetically designed mouse model that faithfully reproduces the natural history of this tumour. It has also been shown that the elimination of the c-Raf protein produces very tolerable toxic effects. This opens up a...

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RPAP1 regulates the activity of RNA polymerase II by means of its interaction with gene transactivat

Cell Reports

The RPAP1 protein, essential for cell identity and viability

Madrid, 18 January, 2018

The regulation of the activity of RNA polymerase II, which catalyses the transcription of DNA in order to generate messenger RNA, is central to cell differentiation and the maintenance of cell identity. RPAP1 is a protein associated with this enzyme whose function in mammals was unknown up until now. A study carried out at the Spanish National Cancer Research Centre (CNIO) and the Institute for Research in Biomedicine (IRB) in Barcelona, demonstrates its key role in establishing and preserving...

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