Home > About Us > CNIO Publications

CNIO Publications

Nucleic Acids Research

Human genome could contain up to 20% fewer genes

Madrid, 30 August, 2018

A new study led by the Spanish National Cancer Research Centre (CNIO) reveals that up to 20% of genes classified as coding (those that produce the proteins that are the building blocks of all living things) may not be coding after all because they have characteristics that are typical of non-coding or pseudogenes (obsolete coding genes). The consequent reduction in the size of the human genome could have important effects in biomedicine since the number of genes that produce proteins and their...

Read more...

Nature Communications

First indicators of prognosis for the most aggressive type of breast cancer

Madrid, 29 August, 2018

The rarest, but also the most aggressive and hard to treat form of breast cancer, is known as triple negative. For this type of cancer, researchers have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments. Researchers from the Spanish National Cancer Research Centre (CNIO) are now publishing in Nature Communications a successful classification of triple breast cancer patients, which for the first time discriminates...

Read more...
Telomerase gene therapy do not increase the risk of cancer

PLoS Genetics

Gene therapy vectors carrying the telomerase gene do not increase the risk of cancer

Madrid, 20 August, 2018

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway against idiopathic pulmonary fibrosis and other diseases associated to short telomeres is in fact safe. Researchers from the Spanish National Cancer Research Centre (CNIO) have shown in a new study that the gene therapy with telomerase that they have developed, and which has proven to be effective in...

Read more...
Discovery of a new tumour suppressor previously thought to be an oncogene

Nature Communications

Discovery of a new tumour suppressor previously thought to be an oncogene

Madrid, 7 August, 2018

A gene that has for decades been considered a tumour promoter, the Plk1 gene, can also perform the exact opposite function: halting the development of cancer. This finding was made by researchers from CNIO and DKFZ, in Germany, and is being published this week in the journal Nature Communications. The role of PLK1 as a target for powerful drugs must now be reviewed since, depending on the type of tumour to be treated, it might be useful to inhibit it, or it might not. For the time being, the...

Read more...
pSTAT3+ reactive astrocytes help cancer cells to develop and grow in the brain

Nature Medicine

A new therapy proves effective against brain metastasis

Madrid, 11 June, 2018

A study published in Nature Medicine by a team led by Manuel Valiente, head of the Brain Metastasis Group at the Spanish National Cancer Research Centre (CNIO), shows that the administration of silibinin in patients with brain metastasis reduces lesions without causing any adverse effects. This preliminary trial provides proof of concept that this compound could be a new effective and safe alternative to treat brain metastasis. “We have demonstrated, taking into account all the...

Read more...
Cohesin SA1 and SA2 have different roles in genome 3D organisation

Nature Structural and Molecular Biology

Deciphering the role of cohesin in genome 3D structure helps understanding tumour cells

Madrid, 4 June, 2018

In recent years it has become evident that the spatial organisation of the genome is key for its function. This organisation depends on a number of factors, the cohesin protein complex being one of them. This essential complex is present in the cells in two versions that contain either the SA1 or SA2 subunit. Scientists at the Spanish National Cancer Research Centre (CNIO), the Centre for Genomic Regulation (CRG), and the Centro Nacional de Análisis Genómico (CNAG-CRG) have addressed the...

Read more...
PanDrugs is a novel data-driven method to personalise cancer treatment

Genome Medicine

A novel data-driven method to personalise cancer treatment

Madrid, 31 May, 2018

Identify and prioritise treatment options based on a patient’s profile of genetic alterations is a major challenge in personalised cancer medicine. Data-driven approaches such as PanDrugs can help to this end. This new computational resource has been developed by researchers from the Bioinformatics Unit at the Spanish National Cancer Research Centre (CNIO) and is described in a paper published in Genome Medicine.  A large majority of cancers carry a long list of genetic alterations...

Read more...
TERRAs, the long non-coding RNAs that protect telomeres, are important epigenetic regulators

Nature Communications

TERRA, the RNAs that protect telomeres, are important epigenetic regulators

Madrid, 18 April, 2018

In 2008, the Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre (CNIO) was one of the first to discover TERRAs, long non-coding telomeric RNAs that are transcribed from telomeres are are part of the telomeric chromatin. Since then, this group has set out to decipher the function of these novel and still mysterious telomeric components. In a paper published now in Nature Communications, Maria A Blasco and her collaborators Juan José Montero and...

Read more...
Tumour cells may develop resistance to potential Ras inhibitors

Genes and Development

A potential setback in the personalised medicine of cancer

Madrid, 17 April, 2018

One of the most constant and exhaustive searches in cancer research is for a treatment aimed specifically at the Ras family of genes, the most common oncogenes and those that initiate many of the most lethal tumours. However, the results of this hypothetical treatment may be far less positive than speculated due to a manuscript published in the Genes & Development journal by the Genomic Instability Group at the Spanish National Cancer Research Centre (CNIO). The study shows how cells are...

Read more...
Structure of R2TP observed through high resolution cryo-electron microscopy

Nature Communications

Structure of a protein complex related with cell survival revealed

Madrid, 16 April, 2018

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high-resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer. This achievement has been made possible by using high-resolution cryo-electron microscopy, a technique brought to the CNIO thanks to Óscar Llorca, director of the Structural Biology Programme and lead author on the paper published in Nature Communications.In 2017, the Nobel...

Read more...