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Clinical Research Programme

Director: Vacancy

The Clinical Research Programme (CRP) aims to translate advances in cancer research into the prevention, diagnosis, and treatment of patients. The major goals of the CRP are the conduction of early clinical trials with novel drugs, the discovery of biomarkers of drug action and disease outcome, the implementation of a strategy for personalised medicine, and the launching of a training programme in drug development.

The CRP is composed of 5 Clinical Research Units (CRU) and 1 support Unit. The Gastrointestinal Cancer CRU, led by Manuel Hidalgo until December 2016, studies novel therapeutics and personalised medicine in pancreatic cancer. Miguel Quintela Fandino leads the Breast Cancer CRU that works on the development of kinase and angiogenesis inhibitors in breast cancer, as well as on the understanding of the molecular taxonomy and metabolic vulnerabilities of this disease. The Prostate Cancer CRU, led by David Olmos, explores novel therapeutics and biomarkers of the disease, with a particular interest in understanding DNA damage repair deficiency mechanisms in prostate cancer. The Lung Cancer CRU, headed by Luis PazAres, and the Haematological Malignancies CRU, led by Joaquín Martínez-López - both established as part of an agreement with the Hospital Universitario 12 de Octubre - focus on molecular and preclinical studies in non-small cell lung cancer and in multiple myeloma, respectively. The Molecular Diagnostics Unit, led by Luis Lombardía, provides support to medical professionals of the National Health system and the CRP through the provision of a wide variety of molecular tests that determine alterations in biomarkers involved in cancer. In 2016, the Programme continued the expansion of its clinical trials activities in collaboration with several hospitals in Spain.