Biotechnology Programme

Genomics Core Unit

Head of Unit:  Orlando Domínguez
Overview

The Genomics Unit was established in 2000 for the purpose of providing the cutting-edge technology and services required by the CNIO research community. With the capacity to even interrogate whole genomes in a single assay, technologies such as high-density DNA microarrays and next-generation sequencing (NGS) reveal the genetic diversity of cancer and help to dissect molecular processes. Structural features, such as mutation repertoires, DNA-binding of protein factors, variations in chromatin structure/folding, as well as functional states such as transcriptomic profiles and changes (mRNA, miRNA) are being elucidated with these technologies in order to uncover basic mechanisms, therapeutic targets and prognostic biomarkers. We offer a broad range of products and services, including microarray whole genome gene expression, array comparative genomic hybridisation (aCGH), NGS library preparation for exome sequencing, ChIPseq and RNAseq analysis, transgenic mouse genotyping, human cell line authentication and capillary DNA sequencing.