Home > Research > Scientific Programmes: Cancer Cell Biology Programme > Seve-Ballesteros Foundation Brain Tumour Group

Cancer Cell Biology Programme

Seve-Ballesteros Foundation Brain Tumour Group

Group Leader:  Massimo Squatrito
Overview

A decade of studies has underlined the complexity of the genetic events that characterise the genomic landscapes of common forms of human cancer, including gliomas. While a few cancer genes are mutated at high frequencies (>20%), the greatest number of cancer genes in most patients appear at intermediate frequencies (2–20%) or lower. Strikingly, the functional significance of the vast majority of these alterations still remains elusive. A current high priority in glioma research is to functionally validate candidate genetic alterations in order to distinguish those that are significant for cancer progression and treatment response.

In our laboratory, we use a combination of genomic analyses, mouse models and primary tumour cell cultures, with the main goal of identifying the molecular mechanisms that could provide the basis for novel treatments for glioma patients.