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Structural Biology Programme

Kinases, Protein Phosphorylation and Cancer Group

Group Leader:  Ivan Plaza Menacho
Overview

Our main scientific goal is to understand mechanisms of protein kinase function, regulation and signaling at the atomic and molecular level, and how these mechanisms are corrupted in cancer and disease.

In particular our research focus on the structural and molecular understanding of protein kinase function. How kinases are activated and regulated by posttranslational modifications and allosteric inputs, and how do they assemble into macromolecular protein complexes to transmit signals inside the cell. With special emphasis on how these mechanisms are corrupted in cancer due to oncogenic mutations and other oncogenic insults (e.g. inflammation, DNA-damage,acquired drug resistance). Crucially, such atomic and molecular information can be translated to the design and development of more potent and specific protein kinase inhibitors leading to more effective drugs for the treatment of cancer patients.