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Structural Biology Programme

Kinases, Protein Phosphorylation and Cancer Group

Group Leader:  Ivan Plaza Menacho
Overview

Our research focuses on the structural and molecular understanding of protein kinase function. How protein kinases are activated and regulated by postranslational modifications and allosteric inputs, and how they assemble into macromolecular protein complexes to transmit signals inside the cell. With a special emphasis on how these mechanisms are corrupted in cancer due to oncogenic mutations and other oncogenic insults (inflammation, DNA-damage, acquired drug resistance). Crucially, such atomic and molecular information can be translated into the design and development of more potent and specific protein kinase inhibitors leading eventually to more effective drugs for the treatment of cancer patients.