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Molecular Oncology Programme

Microenvironment & Metastasis Group

Group Leader:  Hector Peinado
Overview

Our laboratory is interested in analysing the main mechanisms involved in tumour-microenvironment communication during metastasis. Extracellular vesicles (EVs) and soluble factors are key players during this process. Tumour cells benefit from the secretion of these factors partly by influencing the behaviour of neighbouring cells in the tumour microenvironment. We are exploring the role of secreted factors and vesicles in metastasis using different approaches: 1) decoding the messages packaged in tumour-derived exosomes during melanoma metastasis, 2) defining novel factors involved in the crosstalk between adipose tissue and tumour, and 3) testing new therapies to prevent metastasis in rare diseases such as neurofibromatosis.