Human Cancer Genetics Programme

Human Genetics Group

Group Leader:  Javier Benítez

For several years, the Human Genetics Group has been working on the understanding of the genetic bases of familial cancer, especially breast cancer. We continue to focus on this activity but have now extended it to include the discovery of new high susceptibility genes that explain families with rare tumours, as well as low susceptibility alleles that can help us to understand the genetic bases of cancer. In addition, we want to define the role of glycosylase genes involved in the base excision DNA repair pathway (BER) across the different phases of the cell cycle, and to explore new alternative treatments based on this pathway.