Molecular Oncology Programme

Tumour Suppression Group

Group Leader:  Manuel Serrano
Overview

Our Group upholds the unifying concept that tumour suppressor genes protect against many types of damage, no matter what the potential detrimental consequences of the damage might be. Tumour suppressors, therefore, confer protection from damage even if that damage is not going to lead to cancer, but to a degenerative disease instead. Cancer protection would thus be just one of the outcomes of tumour suppressors, with other outcomes being protection from degenerative diseases, from nutritional overload, from tissue injuries, or from ageing. We aim to achieve an integrated understanding of the protection provided by tumour suppressors.

Our goals are to:

  • Understand tumour suppression mechanisms and identify new tumour suppressor regulators.
  • Study the interplay between tumour suppression and ageing.
  • Characterise cellular senescence as a tumour suppression mechanism.
  • Investigate cellular pluripotency and the involvement of tumour suppressors in the regulation of reprogramming to pluripotent stem cells.
  • Explore the role(s) of cell plasticity in cancer, tissue regeneration, and ageing.
  • Search for new frontiers in cell plasticity.