Molecular Oncology Programme

Brain Metastasis Group

Group Leader:  Manuel Valiente
Research highlights

We have identified a cell type-specific molecular marker that is present in the brain metastasis microenvironment and absent from the normal brain. This marker is present surrounding both experimental and human metastasis, independent of the source of the primary tumour.

By establishing a mouse model that is unable to activate this component of the microenvironment we have proven its pro metastatic role, since the development of brain metastasis is significantly reduced.

We have translated this finding into a novel therapeutic approachby which we can target brain metastasis by blocking discrete pro-tumorigenic populations within the heterogeneous microenvironment of brain metastasis.