- Maria Dolores Moreno
- Ester Casajús
- Samuel Míguez
- Araceli Grande
Safeguarding the genetic information is essential to all forms of life. Two key cellular processes keep it free from errors: DNA replication and repair. Importantly, when these do not work correctly, genetic information may be damaged or lost, ultimately leading to disease. Deregulation and malfunction of the protein machinery that safeguards our genome are a hallmark of cancer, but it remains unclear how this happens at the molecular level. The devil is in the detail, and we aim to understand to the highest level of detail what and when things can go wrong with these molecular machines, so we can act on it to correct it and prevent it from happening.
These macromolecules are like real life machines, with intricate mechanisms that enable them to perform their activities. To understand how they work, we use cryo-electron microscopy and biochemistry in an integrative approach. Beyond fundamental research, this structural information provides the necessary detail for drug development.
- (2019). Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Proc Natl Acad Sci USA 116, 11229-11234. CNIO Publication.
- (2019). CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines. Mol Cancer Res 13, 720-730. CNIO Publication.
- (2018). Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J Biol Chem 293, 18903-18913. CNIO Publication.