Crystallography and Protein Engineering Unit

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Staff Scientists

  • Jorge Luís Martínez

Post-Doctoral Fellows

  • Yudhi Nugraha

Technicians

  • Aida Contreras
  • Lluvia Rebollo
  • Pilar Redondo

The Crystallography and Protein Engineering Unit (XTPEUnit) is a core facility created to provide on-demand services at different levels to fulfil the needs of our users. By offering services ranging from protein cloning to solving the 3D structures of proteins, we help our users to further comprehend how target proteins work. With this purpose in mind, we produce proteins for different types of biochemical/biophysical/in vitro/in vivo assays and for monoclonal antibody production, also offering macromolecular structural determination at high-resolution (atomic) by X-ray crystallography, and at low-resolution in-solution by small-angle X-ray scattering (SAXS). Protein co-crystallisation, in the presence of inhibitors or small fragments, is routinely done in our laboratory in combination with studies on protein thermal stability (thermofluor assay), to accelerate the guided drug discovery process.

Publications

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