Computational Oncology Group

Home | Research & Innovation | Scientific Programmes | Structural Biology Programme | Computational Oncology Group

Geoffrey John Macintyre
Geoffrey John Macintyre Group Leader
T +34 (+34) 917 328 000 (Ext )
gmacintyre@cnio.es

Post-Doctoral Fellows

  • Bárbara Hernando

Graduate Students

  • María Escobar
  • Ángel Fernández
  • Joseph Sneath Thompson

Visiting Scientist

  • Diego García

In the Computational Oncology Group, we are tackling some of the deadliest cancers by targeting the causes of chromosomal instability. Pancreatic, oesophageal, lung and ovarian cancers have some of the lowest survival rates, but they also share a common trait, which we can exploit − extreme chromosomal instability (CIN). By therapeutically targeting CIN, we aim to improve outcomes in these tumours.

Our main research areas include:

  • Using model systems to develop therapeutic strategies to target CIN.
  • Predicting therapy response using genomic signatures of CIN in patient biopsies.
  • Developing single cell sequencing approaches to detect ongoing CIN.

We are applying these technologies at the earliest stages of tumour development in patients with premalignant lesions, with the goal of preventing aggressive, difficult to treat cancers.

Publications

    SELECT dxsjj_posts.* FROM dxsjj_posts LEFT JOIN dxsjj_postmeta ON ( dxsjj_posts.ID = dxsjj_postmeta.post_id ) LEFT JOIN dxsjj_postmeta AS mt1 ON ( dxsjj_posts.ID = mt1.post_id AND mt1.meta_key = 'factor_impacto' ) LEFT JOIN dxsjj_postmeta AS mt2 ON ( dxsjj_posts.ID = mt2.post_id ) LEFT JOIN dxsjj_postmeta AS mt3 ON ( dxsjj_posts.ID = mt3.post_id ) LEFT JOIN dxsjj_postmeta AS mt4 ON ( dxsjj_posts.ID = mt4.post_id ) WHERE 1=1 AND ( ( dxsjj_postmeta.meta_key = 'factor_impacto' OR mt1.post_id IS NULL ) AND mt2.meta_key = 'autores' AND ( mt3.meta_key = 'id_grupos' AND mt3.meta_value LIKE '{1b64f7b3a9e39913c9e926426f3ce7d8210c460f2dc1a196c013afb6d78b915b}50011330{1b64f7b3a9e39913c9e926426f3ce7d8210c460f2dc1a196c013afb6d78b915b}' ) AND ( mt4.meta_key = 'anyo' AND CAST(mt4.meta_value AS SIGNED) >= '2018' ) ) AND dxsjj_posts.post_type = 'cnio_publication' AND ((dxsjj_posts.post_status = 'publish')) GROUP BY dxsjj_posts.ID ORDER BY CAST(mt4.meta_value AS SIGNED) DESC, CAST(dxsjj_postmeta.meta_value AS SIGNED) DESC, CAST(mt2.meta_value AS CHAR) ASC

  • Hernando B, Macintyre G. (2023). A medley of resistance in ovarian cancers. Nat Genet 55, 361-362. CNIO Publication.
  • Calsina B, Piñeiro-Yáñez E, Martínez-Montes ÁM, Caleiras E, Fernández-Sanromán Á, Monteagudo M, Torres-Pérez R, Fustero-Torre C, Pulgarín-Alfaro M, Gil E, Letón R, Jiménez S, García-Martín S, Martin MC, Roldán-Romero JM, Lanillos J, Mellid S, Santos M, Díaz-Talavera A, Rubio Á, González P, Hernando B, Bechmann N, Dona M, Calatayud M, Guadalix S, Álvarez-Escolá C, Regojo RM, Aller J, Del Olmo-Garcia MI, López-Fernández A, Fliedner SMJ, Rapizzi E, Fassnacht M, Beuschlein F, Quinkler M, Toledo RA, Mannelli M, Timmers HJ, Eisenhofer G, Rodríguez-Perales S, Domínguez O, Macintyre G, Currás-Freixes M, Rodríguez-Antona C, Cascón A, Leandro-García LJ, Montero-Conde C, Roncador G, García-García JF, Pacak K, Al-Shahrour F, Robledo M. (2023). Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma. Nat Commun 14, 1122. CNIO Publication.
  • Wilson A, Chiu DS, Cushing-Haugen KL, Fereday S, Garsed DW, Gayther SA, Gentry-Maharaj A, Gilks B, Jimenez-Linan M, Kennedy CJ, Le ND, Piskorz AM, Riggan MJ, Shah M, Singh N, Talhouk A, Widschwendter M, Bowtell DDL, Candido Dos Reis FJ, Cook LS, Fortner RT, García MJ, Harris HR, Huntsman DG, Karnezis AN, Köbel M, Menon U, Pharoah PDP, Doherty JA, Anglesio MS, Pike MC, Pearce CL, Friedlander ML, DeFazio A, Nelson BH, Ramus SJ. (2023). Profiling the immune landscape in mucinous ovarian carcinoma. Gynecol Oncol 168, 23-31. CNIO Publication.
  • Drews RM, Hernando B, Tarabichi M, Haase K, Lesluyes T, Smith PS, Morrill Gavarró L, Couturier DL, Liu L, Schneider M, Brenton JD, Van Loo P, Macintyre G, Markowetz F (2022). A pan-cancer compendium of chromosomal instability. Nature 606, 976-983. CNIO Publication.
  • Chaves-Urbano B, Hernando B, Garcia MJ, Macintyre G. (2022). CNpare: matching DNA copy number profiles. Bioinformatics 38, 3638-3641. CNIO Publication.
  • Gallego A, Mendiola M, Hernando B, Berjon A, Cadiz A, Chaves-Urbano B, Heredia-Soto V, Spagnolo E, Hernández Gutiérrez A, Hardisson D, Macintyre G, Redondo A, Garcia MJ (2022). Prognostic markers of inflammation in endometrioid and clear cell ovarian cancer. Int J Gynecol Cancer 32, 1009-1016. CNIO Publication.
  • Jiménez-Sánchez A, Cybulska P, Mager KL, Koplev S, Cast O, Couturier DL, Memon D, Selenica P, Nikolovski I, Mazaheri Y, Bykov Y, Geyer FC, Macintyre G, Gavarró LM, Drews RM, Gill MB, Papanastasiou AD, Sosa RE, Soslow RA, Walther T, Shen R, Chi DS, Park KJ, Hollmann T, Reis-Filho JS, Markowetz F, Beltrao P, Vargas HA, Zamarin D, Brenton JD, Snyder A, Weigelt B, Sala E, Miller ML. (2020). Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of Chemotherapy. Nat Genet 52, 582-593. CNIO Publication.

Up