Computational Oncology Group

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Geoffrey John Macintyre
Geoffrey John Macintyre Group Leader
T +34 (+34) 917 328 000 (Ext )
gmacintyre@cnio.es

Research Scientists

  • Patricia González

Post-Doctoral Fellows

  • Bárbara Hernando
  • Marina Torres

Graduate Students

  • Blas Chaves
  • María Escobar
  • Joseph Sneath Thompson
  • Sylvie Van Genderen

Technicians

  • Alice Nicole Cádiz
  • Ángel Fernández

Visiting Scientist

  • María José García

In the Computational Oncology Group, we are tackling some of the deadliest cancers by targeting the causes of chromosomal instability (CIN). By therapeutically targeting CIN, we aim to improve patient outcomes.

Our main research areas include:

  • Using model systems to develop therapeutic strategies to target CIN.
  • Predicting therapy response using CIN signatures in patient biopsies.
  • Developing single cell sequencing approaches for ultrasensitive CIN detection.

We aim to apply these technologies at the earliest stages of tumour development in patients with premalignant lesions, with the goal of preventing aggressive, difficult to treat cancers.

Publications

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  • Loras A, Gil-Barrachina M, Hernando B, Perez-Pastor G, Martinez-Domenech A, Mahiques L, Pitarch G, Valcuende-Cavero F, Ballester-Sanchez R, Marques-Torrejon MA, Martinez-Cadenas C. (2024). Association between several immune response-related genes and the effectiveness of biological treatments in patients with moderate-to-severe psoriasis. Exp Dermatol 33, e15003. CNIO Publication.
  • Schneider MP, Cullen AE, Pangonyte J, Skelton J, Major H, Van Oudenhove E, Garcia MJ, Chaves Urbano B, Piskorz AM, Brenton JD, Macintyre G, Markowetz F (2024). scAbsolute: measuring single-cell ploidy and replication status. Genome Biol Evol 25, 62. CNIO Publication.
  • Hernando B, Macintyre G. (2023). A medley of resistance in ovarian cancers. Nat Genet 55, 361-362. CNIO Publication.
  • Calsina B, Piñeiro-Yáñez E, Martínez-Montes ÁM, Caleiras E, Fernández-Sanromán Á, Monteagudo M, Torres-Pérez R, Fustero-Torre C, Pulgarín-Alfaro M, Gil E, Letón R, Jiménez S, García-Martín S, Martin MC, Roldán-Romero JM, Lanillos J, Mellid S, Santos M, Díaz-Talavera A, Rubio Á, González P, Hernando B, Bechmann N, Dona M, Calatayud M, Guadalix S, Álvarez-Escolá C, Regojo RM, Aller J, Del Olmo-Garcia MI, López-Fernández A, Fliedner SMJ, Rapizzi E, Fassnacht M, Beuschlein F, Quinkler M, Toledo RA, Mannelli M, Timmers HJ, Eisenhofer G, Rodríguez-Perales S, Domínguez O, Macintyre G, Currás-Freixes M, Rodríguez-Antona C, Cascón A, Leandro-García LJ, Montero-Conde C, Roncador G, García-García JF, Pacak K, Al-Shahrour F, Robledo M. (2023). Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma. Nat Commun 14, 1122. CNIO Publication. Open Access Open Access
  • Wilson A, Chiu DS, Cushing-Haugen KL, Fereday S, Garsed DW, Gayther SA, Gentry-Maharaj A, Gilks B, Jimenez-Linan M, Kennedy CJ, Le ND, Piskorz AM, Riggan MJ, Shah M, Singh N, Talhouk A, Widschwendter M, Bowtell DDL, Candido Dos Reis FJ, Cook LS, Fortner RT, García MJ, Harris HR, Huntsman DG, Karnezis AN, Köbel M, Menon U, Pharoah PDP, Doherty JA, Anglesio MS, Pike MC, Pearce CL, Friedlander ML, DeFazio A, Nelson BH, Ramus SJ. (2023). Profiling the immune landscape in mucinous ovarian carcinoma. Gynecol Oncol 168, 23-31. CNIO Publication.
  • Drews RM, Hernando B, Tarabichi M, Haase K, Lesluyes T, Smith PS, Morrill Gavarró L, Couturier DL, Liu L, Schneider M, Brenton JD, Van Loo P, Macintyre G, Markowetz F (2022). A pan-cancer compendium of chromosomal instability. Nature 606, 976-983. CNIO Publication.
  • Chaves-Urbano B, Hernando B, Garcia MJ, Macintyre G. (2022). CNpare: matching DNA copy number profiles. Bioinformatics 38, 3638-3641. CNIO Publication.
  • Gallego A, Mendiola M, Hernando B, Berjon A, Cadiz A, Chaves-Urbano B, Heredia-Soto V, Spagnolo E, Hernández Gutiérrez A, Hardisson D, Macintyre G, Redondo A, Garcia MJ (2022). Prognostic markers of inflammation in endometrioid and clear cell ovarian cancer. Int J Gynecol Cancer 32, 1009-1016. CNIO Publication.
  • Jiménez-Sánchez A, Cybulska P, Mager KL, Koplev S, Cast O, Couturier DL, Memon D, Selenica P, Nikolovski I, Mazaheri Y, Bykov Y, Geyer FC, Macintyre G, Gavarró LM, Drews RM, Gill MB, Papanastasiou AD, Sosa RE, Soslow RA, Walther T, Shen R, Chi DS, Park KJ, Hollmann T, Reis-Filho JS, Markowetz F, Beltrao P, Vargas HA, Zamarin D, Brenton JD, Snyder A, Weigelt B, Sala E, Miller ML. (2020). Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of Chemotherapy. Nat Genet 52, 582-593. CNIO Publication.

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