Computational Oncology Group

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Geoffrey John Macintyre
Geoffrey John Macintyre Group Leader
T +34 (+34) 917 328 000 (Ext )
gmacintyre@cnio.es

Staff Scientists

  • María José García

Post-Doctoral Fellows

  • Bárbara Hernando

Graduate Students

  • Ángel Fernández

Technicians

  • Alice Nicole Cádiz
  • Blas Chaves
  • María Escobar

In the Computational Oncology Group, we are tackling some of the deadliest cancers by targeting the causes of chromosomal instability. Pancreatic, oesophageal, lung and ovarian cancers have some of the lowest survival rates, but they also share a common trait, which we can exploit − extreme chromosomal instability (CIN). By therapeutically targeting CIN, we aim to improve outcomes in these tumours.

Our main research areas include:

  • Using model systems to develop therapeutic strategies to target CIN.
  • Predicting therapy response using genomic signatures of CIN in patient biopsies.
  • Developing single cell sequencing approaches to detect ongoing CIN.

We are applying these technologies at the earliest stages of tumour development in patients with premalignant lesions, with the goal of preventing aggressive, difficult to treat cancers.

Publications

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  • Drews RM, Hernando B, Tarabichi M, Haase K, Lesluyes T, Smith PS, Morrill Gavarró L, Couturier DL, Liu L, Schneider M, Brenton JD, Van Loo P, Macintyre G, Markowetz F (2022). A pan-cancer compendium of chromosomal instability. Nature 606, 976-983. CNIO Publication.
  • Gallego A, Mendiola M, Hernando B, Berjon A, Cadiz A, Chaves-Urbano B, Heredia-Soto V, Spagnolo E, Hernández Gutiérrez A, Hardisson D, Macintyre G, Redondo A, Garcia MJ (2022). Prognostic markers of inflammation in endometrioid and clear cell ovarian cancer. Int J Gynecol Cancer 32, 1009-1016. CNIO Publication.
  • Jiménez-Sánchez A, Cybulska P, Mager KL, Koplev S, Cast O, Couturier DL, Memon D, Selenica P, Nikolovski I, Mazaheri Y, Bykov Y, Geyer FC, Macintyre G, Gavarró LM, Drews RM, Gill MB, Papanastasiou AD, Sosa RE, Soslow RA, Walther T, Shen R, Chi DS, Park KJ, Hollmann T, Reis-Filho JS, Markowetz F, Beltrao P, Vargas HA, Zamarin D, Brenton JD, Snyder A, Weigelt B, Sala E, Miller ML. (2020). Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of Chemotherapy. Nat Genet 52, 582-593. CNIO Publication.

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