- Nuria Gago
- David Olmeda
- Susana Frago
- Xavier Catena
- Marta Contreras
- Cristina Tejedo
- Tonantzin Guadalupe Calvo
- Estela Cañón
Melanomas are a prime example of how basic and translational research has been translated into improved prognosis for affected patients. Nevertheless, clinical responses are still incomplete. The long-term goals of our Group are to identify new progression biomarkers and therapeutic agents. Focusing on stress response programmes involving apoptosis, autophagy and endosome mobilisation, we have discovered lineage-specific oncogenes that define the melanoma ‘fingerprint’. Transcriptomic and proteomic analyses of the melanoma secretome have enabled us to define how tumour cells remodel the (lymph)angiogenic vasculature and avoid immune recognition. Moreover, we have generated a unique set of animal models for non-invasive imaging of melanoma progression in vivo. These systems have led to the validation of nanoparticle-based treatments that are currently being tested in clinical trials. Our ultimate objective is to improve the management of patients with otherwise refractory metastatic melanomas.
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- (2019). KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene (in press).
- (2018). CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism. Sci Rep 8, 3357.
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- (2016). The nuclear corepressor 1 and the thyroid hormone receptor ß suppress breast tumor lymphangiogenesis.. Oncotarget 7, 78971-78984.
- (2016). The state of melanoma: challenges and opportunities.. Pigment Cell Melanoma Res 29, 404-416.
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- (2016). Metastatic risk and resistance to BRAF inhibitors in melanoma defined by selective allelic loss of ATG5.. Autophagy 12, 1776-1790.
- (2015). RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development.. Oncotarget 6, 11848-11862.
- (2015). Hyperactivated endolysosomal trafficking in melanoma.. Oncotarget 6, 2583-2584.
- (2015). Let’s make it happen: for gender equality in science!. Pigment Cell Melanoma Res 28, 641-642.
- (2015). Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis.. Fertil Steril 104, 1310-1318.
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