- Vanesa Lafarga
- Matilde Murga
- Elena Fueyo
- Antonio Galarreta
- Gema López
- Laura Sánchez
- Oleksandra Sirozh
- Pablo Valledor
- Marta Elena Antón
- Alicia González
- Sara Rodrigo
In the Genomic Instability Group, our aim is to obtain a mechanistic understanding of cancer and other age-related diseases, and then use this information to develop new therapies. To this end, we combine molecular and cellular biology approaches with chemical and genetic screens. In addition, we also develop mouse models of disease, which we can later use as platforms for testing new treatments.
Using these tools, in recent years, we have made exciting discoveries in several areas such as mechanisms of resistance to cancer therapies, targeting nucleolar stress in cancer, drug development and neurodegeneration. Ultimately, our objective is to find new or better treatments for human disease.
- (2020). Supraphysiological protection from replication stress does not extend mammalian lifespan.. Aging (Albany NY) 12, 5612-5624. CNIO Publication.
- (2020). GRK2-Dependent HuR Phosphorylation Regulates HIF1a Activation Under Hypoxia or Adrenergic Stress. Cancers 12, E1216. CNIO Publication. Open Access
- (2020). ATR expands embryonic stem cell fate potential in response to replication stress. Elife 12, e54756. CNIO Publication. Open Access
- (2019). A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells.. Cell Reports 28, 597-604. CNIO Publication. Open Access
- (2019). A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats. Cell Chem Biol 26, 235-243. CNIO Publication.
- (2019). BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Mol Cell 73, 1267-1281. CNIO Publication.
- (2019). TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO Rep 20, e46224. CNIO Publication.
- (2019). Nucleolin reorganization and nucleolar stress in purkinje cells of mutant PCD mice. Neurobiol Dis 127, 312-322. CNIO Publication.
- (2019). TIAR controls mitotic entry, maintains genome stability and retains CDK1 in checkpoint bodies.. EMBO Rep 20, pii: e46224. CNIO Publication.
- (2018). USP7 couples DNA replication termination to mitotic entry. bioRxiv (in press). CNIO Publication.
- (2018). DNA and RNA binding mediate the toxicity of arginine-rich peptides encoded by C9ORF72 GGGGCC repeats. bioRxiv (in press). CNIO Publication.
- (2018). Targeting ATR in cancer. Nat Rev Cancer 18, 586-595. CNIO Publication.
- (2018). ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes Dev 32, 568-576. CNIO Publication. Open Access
- (2018). The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Reports 22, 396-410. CNIO Publication. Open Access
- (2018). CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN. Cell Mol Life Sci 75, 527-576. CNIO Publication.
- (2018). ATR is required to complete meiotic recombination in mice. Nat Commun 9, 2622. CNIO Publication. Open Access
- (2017). TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.. J Mol Biol 429, 2780-2789. CNIO Publication.
- (2017). A p53-dependent response limits the viability of mammalian haploid cells.. Proc Natl Acad Sci USA 114, 9367-9372. CNIO Publication.
- (2016). USP7 is a SUMO deubiquitinase essential for DNA replication.. Nat Struct Mol Biol 23, 270-277. CNIO Publication.
- (2016). Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature 535, 382-387. CNIO Publication.
- (2016). POLD3 Is Haploinsufficient for DNA Replication in Mice. Mol Cell 63, 877-883. CNIO Publication.
- (2016). A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors. Mol Cell 62, 307-313. CNIO Publication.
- (2016). Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.. Sci Signal 9, ra91. CNIO Publication.
- (2016). Efficacy of ATR inhibitors as single agents in Ewing sarcoma. Oncotarget 7, 58759-58767. CNIO Publication. Open Access
- (2016). A SUMO and ubiquitin code coordinates protein traffic at replication factories.. Bioessays 38, 1209-1217. CNIO Publication.
- (2016). The (elusive) role of the SMC5/6 complex.. Cell Cycle 15, 775-776. CNIO Publication.
- (2015). Hopes for the year ahead.. Nature 517, 111-113. CNIO Publication.
- (2015). Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun 6, 8548. CNIO Publication. Open Access
- (2015). PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.. Cell Death Differ 22, 1144-1157. CNIO Publication.
- (2015). Reducing genomic instability in iPSCs.. Oncotarget 6, 34045-34046. CNIO Publication.
- (2015). A single conserved residue mediates binding of the ribonucleotide reductase catalytic subunit RRM1 to RRM2 and is essential for mouse development.. Mol Cell Biol 35, 2910-2917. CNIO Publication.
- (2015). Modeling the study of DNA damage responses in mice.. Methods Mol Biol 1267, 413-437. CNIO Publication.
- (2015). Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev 29, 690-695. CNIO Publication. Open Access
- (2015). Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nat Commun 6, 8036. CNIO Publication. Open Access
- (2015). NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.. EMBO J 34, 2604-2619. CNIO Publication.