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Post-Doctoral Fellows
- Begoña Hurtado
- Carolina Villarroya
Graduate Students
- Mariona Cubells
- José González
- Luis Rodrigo López
- Diego Martínez
- Borja Pitarch
Technicians
- Irene Díaz
- Aicha El Bakkali
The Cell Division and Cancer Group is interested in deciphering the mechanisms by which cell division and cell proliferation are regulated in a variety of mammalian cell types. Our scientific interests are: i) to understand the basic control mechanisms that regulate the cell division cycle; ii) to characterise the physiological and therapeutic consequences of cell cycle deregulation; iii) understanding self-renewal and pluripotency in stem cell biology and tumour development; and iv) finding and validating new targets for cancer therapy. As a final goal, we aim to generate information that will be useful for understanding basic mechanisms of cell function and to improve therapeutic strategies against cancer cell proliferation.
Publications
- (2020). Transient Exposure to miR-203 Enhances the Differentiation Capacity of Established Pluripotent Stem Cells. EMBO J 39, e104324. CNIO Publication.
- (2020). CDK4/6 inhibitors impair recovery from cytotoxic chemotherapy in pancreatic adenocarcinoma.. Cancer Cell 37, 340-353. CNIO Publication.
- (2020). Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Cell Death Differ 27, 2451-2467. CNIO Publication.
- (2020). Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition.. Cancer Cell 37, 514-529. CNIO Publication.
- (2020). Mammalian cell cycle cyclins.. Semin Cell Dev Biol 107, 28-35. CNIO Publication.
- (2020). Effects of energy metabolism on the mechanical properties of breast cancer cells. Commun Biol 3, 590. CNIO Publication.
- (2020). Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135. bioRxiv (in press). CNIO Publication.
- (2020). Molecular Basis of the Mechanisms controlling MASTL.. Mol Cell Proteomics 19, 326-343. CNIO Publication.
- (2019). p38? is essential for cell cycle progression and liver tumorigenesis. Nature 568, 557-560. CNIO Publication.
- (2019). CDK4/6 inhibitors: what is the best cocktail?. Clin Cancer Res 25, 6-8. CNIO Publication.
- (2019). CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines. Mol Cancer Res 13, 720-730. CNIO Publication.
- (2019). Aurora A controls CD8+ T cell cytotoxic activity and antiviral response. Sci Rep 3, 2211. CNIO Publication.
Open Access
- (2019). Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. Oncogene 38, 4620-4636. CNIO Publication.
- (2019). Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma. Sci Rep 9, 5179. CNIO Publication.
Open Access
- (2018). CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. Cancer Discovery 8, 884-897. CNIO Publication.
- (2018). Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeleton dynamics in platelets. J Clin Invest 128, 5351-5367. CNIO Publication.
Open Access
- (2018). Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat Commun 9, 3012. CNIO Publication.
Open Access
- (2018). An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res 46, 4546-4559. CNIO Publication.
Open Access
- (2018). Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis. Curr Biol 28, 3458-3468. CNIO Publication.
- (2018). Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ 25, 828-840. CNIO Publication.
- (2018). Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci Rep 8, 11871. CNIO Publication.
Open Access
- (2018). RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. Bmc Cancer 18, 430. CNIO Publication.
Open Access
- (2018). Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells. Curr Biol 28, 3824-3832. CNIO Publication.
- (2017). Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M.. Cell Death Differ (in press). CNIO Publication.
- (2017). Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.. Nat Med 23, 964-974. CNIO Publication.
- (2017). SnapShot: phosphoregulation of mitosis. Cell 169, 1358-1358e1. CNIO Publication.
- (2017). Fueling the Cell Division Cycle.. Trends Cell Biol 27, 69-81. CNIO Publication.
- (2017). The anaphase promoting complex impacts repair choice by protecting ubiquitin signaling at DNA damage sites. Nat Commun 8, 15751. CNIO Publication.
Open Access
- (2017). Programmed mitophagy is essential for the glycolytic switch during cell differentiation.. EMBO J 36, 1688-1706. CNIO Publication.
- (2017). APC/CCdh1 enables removal of shugoshin-2 from the arms of bivalent chromosomes by moderating cyclin-dependent kinase activity. Curr Biol 27, 1462-1476. CNIO Publication.
- (2016). Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.. Nat Rev Mol Cell Bio 17, 280-292. CNIO Publication.
- (2016). CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER2(+) Breast Cancer.. Cancer Cell 29, 243-244. CNIO Publication.
- (2016). Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.. Cell Res 26, 699-712. CNIO Publication.
- (2016). Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun 7, 11389. CNIO Publication.
Open Access
- (2016). E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res 44, 5557-5570. CNIO Publication.
Open Access
- (2016). The cell proliferation antigen Ki-67 organises heterochromatin. Elife 5, e13722. CNIO Publication.
Open Access
- (2016). An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.. Cell Death Differ 23, 430-441. CNIO Publication.
- (2016). microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. CNIO Publication.
Open Access
- (2016). Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.. Cell Discov 2, 15044. CNIO Publication.