Cell Division and Cancer Group

Marcos Malumbres Group Leader
T +34 917328000 (Ext 3450)
mmm@cnio.es

Post-Doctoral Fellows

Begoña Hurtado
Carolina Villarroya

Graduate Students

Mariona Cubells
José González
Luis Rodrigo López
Diego Martínez
Borja Pitarch

Technicians

Irene Díaz
Aicha El Bakkali

The Cell Division and Cancer Group is interested in deciphering the mechanisms by which cell division and cell proliferation are regulated in a variety of mammalian cell types. Our scientific interests are: i) to understand the basic control mechanisms that regulate the cell division cycle; ii) to characterise the physiological and therapeutic consequences of cell cycle deregulation; iii) understanding self-renewal and pluripotency in stem cell biology and tumour development; and iv) finding and validating new targets for cancer therapy. As a final goal, we aim to generate information that will be useful for understanding basic mechanisms of cell function and to improve therapeutic strategies against cancer cell proliferation.

Publications

Salazar-Roa M, Trakala M, Álvarez-Fernández M, Valdés-Mora F, Zhong C, Muñoz J, Yu Y, Peters TJ, Graña-Castro O, Serrano R, Zapatero-Solana E, Abad M, Bueno MJ, de Cedrón MG, Fernández-Piqueras J, Serrano M, Blasco MA, Wang DZ, Clark SJ, Izpisua-Belmonte JC, Ortega S, Malumbres M (2020). Transient Exposure to miR-203 Enhances the Differentiation Capacity of Established Pluripotent Stem Cells. EMBO J 39, e104324. CNIO Publication.
Salvador-Barbero B, Álvarez-Fernández M, Zapatero-Solana E, El Bakkali A, Menéndez MDC, López-Casas PP, Di Domenico T, Xie T, VanArsdale T, Shields DJ, Hidalgo M, Malumbres M. (2020). CDK4/6 inhibitors impair recovery from cytotoxic chemotherapy in pancreatic adenocarcinoma.. Cancer Cell 37, 340-353. CNIO Publication.
Sanz-Gómez N, de Pedro I, Ortigosa B, Santamaría D, Malumbres M, de Cárcer G, Gandarillas A. (2020). Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Cell Death Differ 27, 2451-2467. CNIO Publication.
Álvarez-Fernández M, Malumbres M (2020). Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition.. Cancer Cell 37, 514-529. CNIO Publication.
Martínez-Alonso D, Malumbres M (2020). Mammalian cell cycle cyclins.. Semin Cell Dev Biol 107, 28-35. CNIO Publication.
Yubero ML, Kosaka PM, San Paulo Á, Malumbres M, Calleja M, Tamayo J (2020). Effects of energy metabolism on the mechanical properties of breast cancer cells. Commun Biol 3, 590. CNIO Publication.
González-Martínez J, Cwetsch AW, Martínez-Alonso D, López-Sainz LR, Almagro J, Megías D, Boskovic J, Gilabert-Juan J, Graña-Castro O, Pierani A, Behrens A, Ortega S, Malumbres M (2020). Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135. bioRxiv (in press). CNIO Publication.
Hermida D, Mortuza GB, Pedersen AK, Pozdnyakova I, Nguyen TTTN, Maroto M, Williamson M, Ebersole T, Cazzamali G, Rand KD, Olsen JV, Malumbres M, Montoya G (2020). Molecular Basis of the Mechanisms controlling MASTL.. Mol Cell Proteomics 19, 326-343. CNIO Publication.
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G (2019). p38? is essential for cell cycle progression and liver tumorigenesis. Nature 568, 557-560. CNIO Publication.
Malumbres M (2019). CDK4/6 inhibitors: what is the best cocktail?. Clin Cancer Res 25, 6-8. CNIO Publication.
Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, González-Corpas A, Barrero MJ (2019). CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines. Mol Cancer Res 13, 720-730. CNIO Publication.
Bustos-Morán E, Blas-Rus N, Alcaraz-Serna A, Iborra S, González-Martínez J, Malumbres M, Sánchez-Madrid F (2019). Aurora A controls CD8+ T cell cytotoxic activity and antiviral response. Sci Rep 3, 2211. CNIO Publication. Open Access
Vázquez-Domínguez I, González-Sánchez L, López-Nieva P, Fernández-Navarro P, Villa-Morales M, Cobos-Fernández MÁ, Sastre I, F Fraga M, F Fernández A, Malumbres M, Salazar-Roa M, Graña-Castro O, Santos J, Llamas P, López-Lorenzo JL, Fernández-Piqueras J (2019). Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. Oncogene 38, 4620-4636. CNIO Publication.
López-Nieva P, Fernández-Navarro P, Graña-Castro O, Andrés-León E, Santos J, Villa-Morales M, Cobos-Fernández MÁ, González-Sánchez L, Malumbres M, Salazar-Roa M, Fernández-Piqueras J (2019). Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma. Sci Rep 9, 5179. CNIO Publication. Open Access
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V (2018). CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. Cancer Discovery 8, 884-897. CNIO Publication.
Hurtado B, Trakala M, Ximénez-Embún P, El-Bakkali A, Partida D, Sanz-Castillo B, Álvarez-Fernández M, Maroto M, Sánchez-Martínez R, Martínez L, Muñoz J, García de Frutos P, Malumbres M (2018). Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeleton dynamics in platelets. J Clin Invest 128, 5351-5367. CNIO Publication. Open Access
de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R (2018). Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat Commun 9, 3012. CNIO Publication. Open Access
Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM (2018). An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res 46, 4546-4559. CNIO Publication. Open Access
Nguyen AL, Drutovic D, Vazquez BN, El Yakoubi W, Gentilello AS, Malumbres M, Solc P, Schindler K (2018). Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis. Curr Biol 28, 3458-3468. CNIO Publication.
Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M (2018). Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Cell Death Differ 25, 828-840. CNIO Publication.
Ovejero S, Ayala P, Malumbres M, Pimentel-Muiños FX, Bueno A, Sacristán MP (2018). Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1. Sci Rep 8, 11871. CNIO Publication. Open Access
López-Nieva P, Fernández-Navarro P, Vaquero-Lorenzo C, Villa-Morales M, Graña-Castro O, Cobos-Fernández MÁ, López-Lorenzo JL, Llamas P, González-Sanchez L, Sastre I, Pollan M, Malumbres M, Santos J, Fernández-Piqueras J (2018). RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. Bmc Cancer 18, 430. CNIO Publication. Open Access
Rata S, Suarez Peredo Rodriguez MF, Joseph S, Peter N, Echegaray Iturra F, Yang F, Madzvamuse A, Ruppert JG, Samejima K, Platani M, Alvarez-Fernandez M, Malumbres M, Earnshaw WC, Novak B, Hochegger H (2018). Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells. Curr Biol 28, 3824-3832. CNIO Publication.
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. (2017). Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M.. Cell Death Differ (in press). CNIO Publication.
de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M. (2017). Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.. Nat Med 23, 964-974. CNIO Publication.
Burgess A, Vuong J, Rogers S, Malumbres M, O'Donoghue SI (2017). SnapShot: phosphoregulation of mitosis. Cell 169, 1358-1358e1. CNIO Publication.
Salazar-Roa M, Malumbres M. (2017). Fueling the Cell Division Cycle.. Trends Cell Biol 27, 69-81. CNIO Publication.
Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li J-M, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P (2017). The anaphase promoting complex impacts repair choice by protecting ubiquitin signaling at DNA damage sites. Nat Commun 8, 15751. CNIO Publication. Open Access
Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P (2017). Programmed mitophagy is essential for the glycolytic switch during cell differentiation.. EMBO J 36, 1688-1706. CNIO Publication.
Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pendás AM, Malumbres M, Novák B, Herbert M, Nasmyth K (2017). APC/CCdh1 enables removal of shugoshin-2 from the arms of bivalent chromosomes by moderating cyclin-dependent kinase activity. Curr Biol 27, 1462-1476. CNIO Publication.
Hydbring P, Malumbres M, Sicinski P (2016). Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.. Nat Rev Mol Cell Bio 17, 280-292. CNIO Publication.
Malumbres M (2016). CDK4/6 Inhibitors resTORe Therapeutic Sensitivity in HER2(+) Breast Cancer.. Cancer Cell 29, 243-244. CNIO Publication.
Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L, Wei W, Zou W (2016). Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.. Cell Res 26, 699-712. CNIO Publication.
Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F (2016). Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun 7, 11389. CNIO Publication. Open Access
Mitxelena J, Apraiz A, Vallejo-Rodríguez J, Malumbres M, Zubiaga AM (2016). E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res 44, 5557-5570. CNIO Publication. Open Access
Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DLj, Feil R, Fisher D (2016). The cell proliferation antigen Ki-67 organises heterochromatin. Elife 5, e13722. CNIO Publication. Open Access
Quereda V, Porlan E, Cañamero M, Dubus P, Malumbres M (2016). An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.. Cell Death Differ 23, 430-441. CNIO Publication.
Correia NC, Melão A, Póvoa V, Sarmento L, Gómez de Cedrón M, Malumbres M, Enguita FJ, Barata JT (2016). microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. Oncotarget 7, 8268-8281. CNIO Publication. Open Access
Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W (2016). Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.. Cell Discov 2, 15044. CNIO Publication.