The Cell Division and Cancer Group is interested in deciphering the mechanisms by which cell division and cell proliferation are regulated in mammalian cells. Our scientific interests are:
To understand the basic control mechanisms that regulate the cell division cycle.
To characterise the physiological and therapeutic consequences of cell cycle deregulation.
Understanding self-renewal and pluripotency in stem cell biology and tumour development.
Improving the use of old and new targets for cancer therapy.
As a final goal, we aim to generate information that will be useful for understanding basic mechanisms of cell function and to improve therapeutic strategies against cancer cell proliferation.
Publications
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Villarroya-Beltri C, Martins AFB, García A, Giménez D, Zarzuela E, Novo M, Del Álamo C, González-Martínez J, Bonel-Pérez GC, Díaz I, Guillamot M, Chiesa M, Losada A, Graña-Castro O, Rovira M, Muñoz J, Salazar-Roa M, Malumbres M. (2022).Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.. EMBO J (in press). CNIO Publication.
Salazar-Roa M, Trakala M, Álvarez-Fernández M, Valdés-Mora F, Zhong C, Muñoz J, Yu Y, Peters TJ, Graña-Castro O, Serrano R, Zapatero-Solana E, Abad M, Bueno MJ, de Cedrón MG, Fernández-Piqueras J, Serrano M, Blasco MA, Wang DZ, Clark SJ, Izpisua-Belmonte JC, Ortega S, Malumbres M (2020).Transient Exposure to miR-203 Enhances the Differentiation Capacity of Established Pluripotent Stem Cells. EMBO J 39, e104324. CNIO Publication.
Martínez-Alonso D, Malumbres M (2020).Mammalian cell cycle cyclins.. Semin Cell Dev Biol 107, 28-35. CNIO Publication.
Hermida D, Mortuza GB, Pedersen AK, Pozdnyakova I, Nguyen TTTN, Maroto M, Williamson M, Ebersole T, Cazzamali G, Rand KD, Olsen JV, Malumbres M, Montoya G (2020).Molecular Basis of the Mechanisms controlling MASTL.. Mol Cell Proteomics 19, 326-343. CNIO Publication.
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G (2019).p38? is essential for cell cycle progression and liver tumorigenesis. Nature 568, 557-560. CNIO Publication.
Vázquez-Domínguez I, González-Sánchez L, López-Nieva P, Fernández-Navarro P, Villa-Morales M, Cobos-Fernández MÁ, Sastre I, F Fraga M, F Fernández A, Malumbres M, Salazar-Roa M, Graña-Castro O, Santos J, Llamas P, López-Lorenzo JL, Fernández-Piqueras J (2019).Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma. Oncogene 38, 4620-4636. CNIO Publication.
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V (2018).CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. Cancer Discovery 8, 884-897. CNIO Publication.
Rata S, Suarez Peredo Rodriguez MF, Joseph S, Peter N, Echegaray Iturra F, Yang F, Madzvamuse A, Ruppert JG, Samejima K, Platani M, Alvarez-Fernandez M, Malumbres M, Earnshaw WC, Novak B, Hochegger H (2018).Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells. Curr Biol 28, 3824-3832. CNIO Publication.
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Open Access