Brain Metastasis Group

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Post-Doctoral Fellows

  • Mariam Al-Masmudi
  • Lluis Cordón
  • Neibla Priego

Graduate Students

  • Laura Adriana Álvaro
  • Jimena Benzal
  • Ana De Pablos
  • Carolina Hernández
  • Irene Salgado
  • Juan José Vázquez

Technicians

  • Patricia Baena
  • Pedro García
  • Jorge Guillermo Ortiz
  • Diana Patricia Retana
  • Oliva Ana Sánchez
  • Catalina Vela

Brain metastasis is the most common neurological complication of cancer and, in spite of the progress made with local (i.e., surgery and radiation) and systemic (i.e., targeted therapy, immunotherapy) therapies, prognosis remains poor. Indeed, the increased incidence of brain metastases is partially due to systemic therapies that work extra-cranially but do not provide the same therapeutic benefit in the brain. We study why and how cells from different cancer types (breast cancer, lung cancer, and melanoma) are able to access the brain, survive, and colonise this vital organ. We dissect the biology of these processes in vivo using experimental models and patient-derived material to challenge this unmet clinical need. Our research has identified novel brain metastasis mediators, characterised the metastasis-associated microenvironment, designed better experimental models, and explored novel methods to target brain metastasis as well as to prevent or revert the frequent impact of metastasis on brain function.

Publications

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