- Mariam Al-Masmudi
- Neibla Priego
- Laura Adriana Álvaro
- Ana De Pablos
- Pedro García
- Pablo Sanz
- Lucía Zhu
- María Isabel García
- Diana Patricia Retana
Brain metastasis is the most common neurological complication of cancer. When metastatic cells reach the brain, prognosis is poor given that local therapies ( i.e. surgery and radiation ) have limited benefits for patients and the disease inevitably progresses. The rise in the number of patients with brain metastasis is partially due to the increasing number of systemic therapies that work extra-cranially but are unable to provide the same therapeutic benefit in the brain. Consequently, cancer cells present at this secondary site have additional time to evolve and to grow into clinically detectable lesions. In the laboratory, we study why and how cells from different cancer types (breast cancer,lung cancer and melanoma) are able to access the brain, survive and colonise this vital organ. We dissect the biology of these processes in vivo using experimental models in order to challenge the current status of this unmet clinical need.
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- (2019). Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol 21, 480. CNIO Publication.
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- (2018). Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol 20, 966-978. CNIO Publication.
- (2018). T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression. Acta Neuropathol 135, 581-599. CNIO Publication.
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- (2017). Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons. Cell Reports 18, 1157-1170. CNIO Publication. Open Access
- (2017). Reactive Astrocytes in Brain Metastasis. Front Oncol 7, 298. CNIO Publication.
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