- Neibla Priego
- Laura Adriana Álvaro
- Catia Patricia Domingues
- Pedro García
- Lucía Zhu
- Lourdes Osuna
- Natalia Yebra
Brain metastasis is the most common neurological complication of cancer. When metastatic cells reach the brain, prognosis is poor given that available therapies (i.e. surgery and radiation) have limited benefits for patients and the disease inevitably progresses. The rise in the number of patients with brain metastasis is partially due to the increasing number of systemic therapies that work extra-cranial but not in the brain. In this scenario, cancer cells present at this highly demanding secondary site have additional time to evolve and develop into clinically detectable lesions. In the laboratory, we study why and how cells from different cancer types (breast cancer, lung cancer and melanoma) are able to access the brain, survive and colonise this vital organ. We dissect the biology of these processes in vivo using experimental models in order to challenge the current status of this unmet clinical need.
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Nat Med 24, 1024-1035.
- Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.(2018)
Nat Cell Biol 20, 966-978.
- T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.(2018)
Acta Neuropathol 135, 581-599.
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- Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion.(2018)
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Trends in Cancer 4, 176-196.
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Cell Reports 18, 1157-1170.
- Reactive Astrocytes in Brain Metastasis.(2017)
Front Oncol 7, 298-.
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Nature 533, 493-498.
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Cell 156, 1002-1016.
- Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.(2014)
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