Our laboratory, in collaboration with Loxo@Lilly Oncology, is working on the identification and validation of novel molecular targets engaged in the induction of chromosomal instability (CIN). Our goal is to find novel therapies that would make tumours bearing CIN more susceptible to destruction, either with the use of single agents, or acting synergistically with other anti-tumour therapies. Exploring how to better target these mechanisms would lead to better and more efficient therapeutic options, including more personalised therapies.
A combination of in vitro and in vivo approaches is being utilised to obtain a complete understanding of the role of CIN in tumour development and anti-tumour response. Each target goes through an in vivo validation process using xenografts, allografts, and mouse models developed at the CNIO that includes the use of non-invasive in vivo imaging technologies, and immune histochemical characterisation of tumours for different metabolic, immune, and tumour markers. The final step is the validation in human samples using tumour tissue arrays.
Publications
SELECT dxsjj_posts.*
FROM dxsjj_posts LEFT JOIN dxsjj_postmeta ON ( dxsjj_posts.ID = dxsjj_postmeta.post_id ) LEFT JOIN dxsjj_postmeta AS mt1 ON ( dxsjj_posts.ID = mt1.post_id AND mt1.meta_key = 'factor_impacto' ) LEFT JOIN dxsjj_postmeta AS mt2 ON ( dxsjj_posts.ID = mt2.post_id ) LEFT JOIN dxsjj_postmeta AS mt3 ON ( dxsjj_posts.ID = mt3.post_id ) LEFT JOIN dxsjj_postmeta AS mt4 ON ( dxsjj_posts.ID = mt4.post_id )
WHERE 1=1 AND (
(
dxsjj_postmeta.meta_key = 'factor_impacto'
OR
mt1.post_id IS NULL
)
AND
mt2.meta_key = 'autores'
AND
( mt3.meta_key = 'id_grupos' AND mt3.meta_value LIKE '{4f757ebbf153e9c67429ef19ee6c0c57ad9b55e93c8525d62dff7b13a4829f85}50004286{4f757ebbf153e9c67429ef19ee6c0c57ad9b55e93c8525d62dff7b13a4829f85}' )
AND
( mt4.meta_key = 'anyo' AND CAST(mt4.meta_value AS SIGNED) >= '2019' )
) AND dxsjj_posts.post_type = 'cnio_publication' AND ((dxsjj_posts.post_status = 'publish'))
GROUP BY dxsjj_posts.ID
ORDER BY CAST(mt4.meta_value AS SIGNED) DESC, CAST(dxsjj_postmeta.meta_value AS SIGNED) DESC, CAST(mt2.meta_value AS CHAR) ASC
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
Strictly Necessary Cookies
Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.
If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.
3rd Party Cookies
This website uses Google Analytics to collect anonymous information such as the number of visitors to the site, and the most popular pages.
Keeping this cookie enabled helps us to improve our website.
Please enable Strictly Necessary Cookies first so that we can save your preferences!
Additional Cookies
This website uses the following additional cookies:
(List the cookies that you are using on the website here.)
Please enable Strictly Necessary Cookies first so that we can save your preferences!