Biology Section

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Research Scientists

  • Pablo Aparicio
  • Marta San Martín

Technicians

  • Antonio Cebriá
  • Claudia Díaz
  • Elena Gómez-Casero

The Biology Section works in early drug discovery projects with the final aim of achieving in vivo proof of concept (PoC) with the lead molecules developed by the Programme. There is a long road before we can select the best or even the first candidate to perform PoC experiments in mice. These molecules have to be novel, potent at both the biochemical and cellular levels, selective, and with good ADME (absorption, distribution, metabolism, and excretion) properties to predict good plasma/tumour levels in mice.

Pharmacokinetic studies allow us to determine if the compounds have achieved plasma levels after intravenous, intraperitoneal, or oral administration, the oral being the preferred route. In vitro and cellular ADME studies help us to identify the liabilities behind the poor oral bioavailability of compounds (i.e., solubility, permeability/efflux or metabolic stability).

Publications

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