The Pediatric Onco-Hematology Clinical Research Unit, headed by Antonio Pérez-Martínez, comprises a multidisciplinary team of physicians, geneticists, biologists, biochemists, and bioinformaticians, who, for the past decade, have carried out projects ranging from knowledge generation to direct clinical application through the development of clinical trials. Our research, which is mostly funded by Fundación Cris Contra el Cáncer, focuses on the design of therapies applied to paediatric oncology, infectious diseases, and paediatric transplantation. Briefly, our research interests include: 1) the use of haematopoietic stem cell transplantation as a platform for cell therapy; 2) the improvement of human stem cell progenitors transplantation in children; 3) cell therapy with memory T lymphocytes as adoptive immunotherapy; and 4) the use of both activated and memory-like NK cells and CART-T cells in paediatric oncology. Together with this, we led several projects aimed at studying the efficacy and feasibility of cell therapy against infectious diseases. Finally, we are also working on the induction of immunological tolerance in solid organ transplantation by inducing mixed haematopoietic chimera through cell therapy. We maintain a strong commitment to patients and to improving their quality of life, having a direct impact on society’s well-being. In this sense, we have several active academic clinical trials and collaborations with industry, with the objective of developing new and more effective therapies with fewer side effects.
Publications
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Ramírez MJ, Pujol R, Minguillón J, Bogliolo M, Persico I, Cavero D, de la Cal A, Río P, Navarro S, Casado JA, Bailador A, de la Fuente AS, de Heredia ML, Almazán F, Antelo ML, Argilés B, Badell I, Baragaño M, Beléndez C, Bermúdez M, Bernués M, Buedo MI, Carrasco E, Català A, Costa D, Cuesta I, Fernandez-Delgado R, Fernández-Teijeiro A, Figuera Á, García M, Gondra A, González M, Muñiz SG, Hernández-Rodríguez I, Ibañez F, Kelleher NJ, Lendínez F, López M, López-Almaraz R, Marchante I, Mendoza C, Nieto J, Ojeda E, Payán-Pernía S, Peláez I, de Soto IP, Portugal R, Ramos-Arroyo MA, Regueiro A, Rodríguez A, Rosell J, Saez R, Sánchez J, Sánchez M, Senent M, Tapia M, Trujillo-Quintero JP, Vagace JM, Verdú-Amorós J, Verdugo V, Vidales I, Villarreal J, Díaz-de-Heredia C, Sevilla J, Bueren JA, Surrallés J. (2025).Prognostic significance of mutation type and chromosome fragility in Fanconi anemia. Am J Hematol 100, 272-284. CNIO Publication.
París-Muñoz A, Alcobendas-Rueda RM, Verdú-Sánchez C, Udaondo C, Galán-Gómez V, González-Martínez B, Menéndez JJ, Martínez-Romera I, Minguillón J, Pertíñez L, de Manuel-Gómez C, de la Cruz-Benito A, Sanz-Rupérez A, Remesal A, Cámara C, Sánchez-Zapardiel E, Del Pino-Molina L, Gómez-Zamora A, Serrano-Olmedo MG, Español-Rego M, Ruiz de Valbuena M, Climent F, Dorao P, Ríos-Blanco JJ, Andrade JD, Ruiz-Zurita G, Fernández-García MA, Pérez-Martínez A. (2025).CD19 CAR-T cell therapy in a pediatric patient with MDA5+ dermatomyositis and rapidly progressive interstitial lung disease. Med (in press). CNIO Publication.
Chen Z, Inague A, Kaushal K, Fazeli G, Schilling D, Xavier da Silva TN, Dos Santos AF, Cheytan T, Freitas FP, Yildiz U, Viviani LG, Lima RS, Pinz MP, Medeiros I, Iijima TS, Alegria TGP, Pereira da Silva R, Diniz LR, Weinzweig S, Klein-Seetharaman J, Trumpp A, Mañas A, Hondal R, Bartenhagen C, Fischer M, Shimada BK, Seale LA, Chillon TS, Fabiano M, Schomburg L, Schweizer U, Netto LE, Meotti FC, Dick TP, Alborzinia H, Miyamoto S, Friedmann Angeli JP. (2024).PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell (in press). CNIO Publication.
Hernández-Blanco C, Al-Akioui-Sanz K, Herrera L, Aguirre-Portolés C, Lozano-Ojalvo D, Pérez-Rodriguez L, Cano-Ochando J, Guerra-García P, Martín-Quirós A, Vicario JL, Santos S, Pérez-Vaquero MÁ, Vesga MÁ, Borobia AM, Carcas AJ, Balas A, Moreno MÁ, Pérez de Diego R, Gasior M, Soria B, Eguizabal C, Pérez-Martínez A. (2024).The phase I RELEASE clinical trial to evaluate the safety of NK cells in COVID-19. iScience 28, 111698. CNIO Publication.
Mingot-Castellano ME, García-Donas G, Campos-Álvarez RM, de Mora MCF, Luis-Navarro J, Domínguez-Rodríguez JF, Del Mar Nieto-Hernández M, Sánchez-Bazán I, Yera-Cobo M, Cardesa-Cabrera R, Jiménez-Gonzalo FJ, Caparrós-Miranda I, Entrena-Ureña L, Herrera SJ, Fernández Jiménez D, Díaz-Canales D, Moreno-Carrasco G, Calderón-Cabrera C, Núñez-Vázquez RJ, Pedrote-Amador B, Jiménez Bárcenas R; Grupo Andaluz de Coagulopatías (GACC). (2024).Use of Eltrombopag to Improve Thrombocytopenia and Tranfusion Requirement in Anti-CD19 CAR-T Cell-Treated Patients. J Clin Med 13, 6294. CNIO Publication.
