H12O – CNIO Haematological Malignancies Clinical Research Unit

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Staff Scientists

  • Santiago Barrio
  • Lucia Virginia Fernández
  • Miguel Gallardo
  • María Linares

Clinical Investigator

  • Rosa María Ayala
  • María Calbacho
  • Gonzalo Carreño
  • María Teresa Cedena
  • Francisco Javier De La Serna
  • Carlos Grande
  • Ana Jiménez
  • Antonia Rodríguez
  • Ricardo Sánchez

Post-Doctoral Fellows

  • Sergio Algar
  • Almudena García
  • Alejandra Leivas
  • María Asunción Martín
  • Antonio Valeri
  • María Velasco

Graduate Students

  • Pedro Aguilar
  • Javier Alcázar
  • Noemí Álvarez
  • Eva Castellano
  • Isabel Cuenca
  • Jessica Encinas
  • Elena Maroto
  • María Alejandra Ortiz
  • Alba Rodríguez
  • Laura Sánchez

Technicians

  • Paula Calvo
  • Adrián Fernández
  • Vanesa Garrido
  • Alicia Giménez
  • María Luz Morales
  • Laura Moreno
  • Miguel Ángel Navarro
  • Laura Rufián

The Haematological Malignancies Laboratory focuses on investigating novel drivers, biomarkers, diagnostic tools and therapeutic targets and approaches in haematological neoplasms such as myeloma and acute myeloid leukaemia.

Five main lines define our research project:

  • Generation of mouse models focused on the molecule hnRNP K, a novel driver of lymphoma and leukaemia.
  • Development of novel diagnostic and follow-up tools, such as minimal residual disease analysis in acute myeloid leukaemia (AML).
  • Screening of novel drivers, biomarkers and therapeutic targets by next-generation-sequencing (NGS, e.g. exome sequencing of amyloidosis).
  • Innovation of immunotherapy approaches. Generation of NK CARs and in vitro/in vivo validation.
  • Novel therapeutic approaches. Screening of novel compounds (e.g. hnRNP K inhibitors) and pre-clinical trials of new drugs or drug combinations.

Publications

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