H12O – CNIO Haematological Malignancies Clinical Research Unit

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Joaquín Martínez
Joaquín Martínez Head of Clinical Research Unit
T +34 (+34) 917 328 000 (Ext )
jmartinezl@ext.cnio.es

Staff Scientists

  • Santiago Barrio
  • Lucia Virginia Fernández
  • Miguel Gallardo
  • María Linares

Clinical Investigator

  • Rosa María Ayala
  • María Calbacho
  • Francisco Javier De La Serna
  • Carlos Grande
  • Ana Jiménez
  • María Inmaculada Rapado
  • Antonia Rodríguez

Post-Doctoral Fellows

  • María del Carmen Fiuza
  • Almudena García
  • María Asunción Martín
  • Ricardo Sánchez
  • Antonio Valeri

Graduate Students

  • Javier Alcázar
  • Sergio Algar
  • Isabel Cuenca
  • Jessica Encinas
  • Alejandra Leivas
  • Elena Maroto
  • María Luz Morales
  • María Alejandra Ortiz
  • Alba Rodríguez
  • Yanira Ruiz
  • Laura Sánchez

Technicians

  • Pedro Aguilar
  • Paula Calvo
  • Adrián Fernández
  • Miguel Ángel Navarro
  • Laura Rufián

The Haematological Malignancies Laboratory focuses on investigating novel drivers, biomarkers, diagnostic tools and therapeutic targets and approaches in haematological neoplasms such as myeloma and acute myeloid leukaemia.

Five main lines define our research project:

  • Generation of mouse models focused on the molecule hnRNP K, a novel driver of lymphoma and leukaemia.
  • Development of novel diagnostic and follow-up tools, such as minimal residual disease analysis in acute myeloid leukaemia (AML).
  • Screening of novel drivers, biomarkers and therapeutic targets by next-generation-sequencing (NGS, e.g. exome sequencing of amyloidosis).
  • Innovation of immunotherapy approaches. Generation of NK CARs and in vitro/in vivo validation.
  • Novel therapeutic approaches. Screening of novel compounds (e.g. hnRNP K inhibitors) and pre-clinical trials of new drugs or drug combinations.

Publications

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