- Lorena Maestre
- Ana Isabel Reyes
The application of hybridoma technology for the production of monoclonal antibodies ( mAbs ) represents one of the most relevant methodological advances in biomedicine of the past decades. The availability of monoclonal antibodies has significantly improved our knowledge about the processes involved in tumour generation and development, opening up a vast array of new possibilities for basic and applied research.
The Monoclonal Antibodies Unit provides CNIO Research Groups with an ‘a? la carte’ generation of mAbs. We are highly specialised in the production of mouse and rat monoclonal antibodies. The Unit also offers mAb characterisation and validation, medium-scale mAb production, as well as a service of Mycoplasma testing for the cell culture facility.
- (2019). Prediction of steroid demand in the treatment of patients with ulcerative colitis by immunohistochemical analysis of the mucosal microenvironment and immune checkpoint: role of macrophages and regulatory markers in disease severity. Pathol Int (in press).
- (2018). Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients. Am J Surg Pathol 42, 936-950.
- (2018). Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features. Oncotarget 9, 16124-16133.
- (2018). Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies. Biomark Insights 13, 1-6.
- (2017). p-MAPK1 expression associated with poor prognosis in angioimmunoblastic T-cell lymphoma patients.. Br J Haematol 176, 661-664.
- (2017). Clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large B-cell lymphoma (DLBCL) reveals gain at 1q31 and RGS1 encoding protein; high RGS1 immunohistochemical expression associates with poor overall survival in DLBCL NOS.. Histopathology 70, 595-621.
- (2017). KLHL6 is preferentially expressed in germinal center-derived B-cell lymphomas.. Am J Clin Pathol 148, 465-476.
- (2017). Almost 2% of Spanish breast cancer families are associated to germline pathogenic mutations in the ATM gene.. Breast Cancer Res Treat 161, 117-134.
- (2016). FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.. Oncotarget 7, 52940-52956.
- (2016). The European antibody network’s practical guide to finding and validating suitable antibodies for research.. MABS 8, 27-36.
- (2016). Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers.. Nat Communications 7, 13418.
- (2015). CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma.. PLoS ONE 10, e0125203.
- (2015). Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene.. J Natl Cancer I 107, djv053.
- (2015). NOTCH pathway inactivation promotes bladder cancer progression.. J Clin Invest 125, 824-830.
- (2015). Functional and in silico assessment of MAX variants of unknown significance.. J Mol Med-Jmm 93, 1247-1255.
- (2014). Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with compromised regulatory T cell function in patients with asthma.. Clin Exp Allergy 44, 1154-1169.
- (2014). Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma.. Hum Pathol 45, 1730-1736.
- (2014). In Response.. Am J Dermatopath 36, 103.
- (2014). Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas.. Biomark Insights 3, 77-84.
- (2014). PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.. PLoS ONE 9, e1121148.
- (2014). Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.. Nat Communications 5, 4226.
- (2013). BCL7A protein expression in normal and malignant lymphoid tissues.. Br J Haematol 160, 106-109.
- (2013). MAP17 and SGLT1 protein expression levels as prognostic markers for cervical tumor patient survival.. PLoS ONE 8, e56169.
- (2013). SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms.. Blood 121, 643-647.