Vacant Director

Pathology is devoted to the study of the structural, biochemical and functional changes in cells, tissues and organs that underlie disease. By using molecular, immunological and morphological techniques, pathology aims to serve as the bridge between basic science and clinical medicine.

The Histopathology Unit offers assistance and expertise through a full range of services covering from paraffin embedding and tissue sections to histochemical stains, research and diagnostic immunohistochemistry (IHC) testing, antibody validation, and in situ hybridisation (ISH), as well as the construction of tissue microarrays. Furthermore, the Unit offers other value added services assisted by a team of highly specialised technicians, such as laser-capture microdissection; slide digitalisation for bright-field, polarisation light and fluorescence; image analysis; and quantification. The Unit collaborates with researchers at any stage of their scientific career in the histological characterisation of phenotypically relevant animal models of disease, thus providing them with the pathology expertise required for the success of their projects.

Publications

• Ferreirós A, Pedrosa P, Da Silva-Álvarez S, Triana-Martínez F, Vilas JM, Picallos-Rabina P, González P, Gómez M, Li H, García-Caballero T, González-Barcia M, Vidal A, Collado M (2019). Context-Dependent Impact of RAS Oncogene Expression on Cellular Reprogramming to Pluripotency. Stem Cell Reports 12, 1099-1112. CNIO Publication. Open Access
• Toledo RA, Garralda E, Mitsi M, Pons T, Monsech J, Vega E, Otero Á, Albarran MI, Baños N, Durán Y, Bonilla V, Sarno F, Camacho-Artacho M, Sanchez-Perez T, Perea S, Álvarez R, De Martino A, Lietha D, Blanco-Aparicio C, Cubillo A, Domínguez O, Martínez-Torrecuadrada JL, Hidalgo M (2018). Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. Clin Cancer Res 24, 3550-3559. CNIO Publication.
• de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R (2018). Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat Commun 9, 3012. CNIO Publication. Open Access
• Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L (2018). A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nat Commun 9, 4809. CNIO Publication. Open Access
• Vilas JM, Carneiro C, Da Silva-Álvarez S, Ferreirós A, González P, Gómez M, Ortega S, Serrano M, García-Caballero T, González-Barcia M, Vidal A, Collado M (2018). Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging. Aging Cell 17, e12834. CNIO Publication. Open Access
• Mosteiro L, Pantoja C, de Martino A, Serrano M (2018). Senescence promotes in vivo reprogramming through p16INK4a and IL-6. Aging Cell 17, 2. CNIO Publication. Open Access
• Puñet-Ortiz J, Sáez Moya M, Cuenca M, Caleiras E, Lazaro A, Engel P (2018). Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland In?ammation in a Mouse Model of Sjögren’s Syndrome. Front Inmmunol 9, 2661. CNIO Publication. Open Access
• de Lucas AG, Schuhmacher AJ, Oteo M, Romero E, Cámara JA, de Martino A, Arroyo AG, Morcillo MÁ, Squatrito M, Martinez-Torrecuadrada JL, Mulero F (2016). Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.. PLoS ONE 11, e0158634. CNIO Publication.
• Hernández-Porras I, Schuhmacher AJ, Garcia-Medina R, Jiménez B, Cañamero M, de Martino A, Guerra C (2016). K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.. J Pathol 239, 206-217. CNIO Publication.
• Mosteiro LL, Pantoja C, Alcazar N, Marión RM, Chondronasiou D, Rovira M, Fernandez-Marcos PJ, Muñoz-Martin M, Blanco-Aparicio C, Pastor J, Gómez-López G, de Martino A, Blasco MA, Abad M, Serrano M (2016). Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.. Science 354, pii: aaf4445.. CNIO Publication.
• González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M (2015). Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development.. Mol Cell Biol 35, 3566-3578. CNIO Publication.