To be appointed Unit Leader

Pathology is devoted to the study of the structural, biochemical and functional changes in cells, tissues and organs that underlie disease. By using molecular, immunological and morphological techniques, pathology aims to serve as the bridge between basic science and clinical medicine.

The Histopathology Unit offers assistance and expertise through a full range of services covering from paraffin embedding and tissue sections to histochemical stains, research and diagnostic immunohistochemistry (IHC) testing, antibody validation, and in situ hybridisation (ISH), as well as the construction of tissue microarrays. Furthermore, the Unit offers other added-value services – for which assistance is provided by a team of highly specialised technicians − such as: laser-capture microdissection; slide digitalisation for bright-field, polarisation light and fluorescence; image analysis; and quantification. The Unit collaborates with researchers at any stage of their scientific career in the histological characterisation of phenotypically relevant animal models of disease, thus providing them with the pathology expertise required for the success of their projects.

Publications

• Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies(2018)
  Toledo RA, Garralda E, Mitsi M, Pons T, Monsech J, Vega E, Otero Á, Albarran MI, Baños N, Durán Y, Bonilla V, Sarno F, Camacho-Artacho M, Sanchez-Perez T, Perea S, Álvarez R, De Martino A, Lietha D, Blanco-Aparicio C, Cubillo A, Domínguez O, Martínez-Torrecuadrada JL, Hidalgo M
  Clin Cancer Res 24, 3550-3559.
• Plk1 overexpression induces chromosomal instability and suppresses tumor development.(2018)
  de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R.
  Nat Commun 9, 3012-.
• Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging.(2018)
  Vilas JM, Carneiro C, Da Silva-Álvarez S, Ferreirós A, González P, Gómez M, Ortega S, Serrano M, García-Caballero T, González-Barcia M, Vidal A, Collado M
  Aging Cell 17, e12834-.
• A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.(2018)
  Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L
  Nat Commun 9, 4809-.
• Senescence promotes in vivo reprogramming through p16INK4a and IL-6.(2018)
  Mosteiro L, Pantoja C, de Martino A, Serrano M.
  Aging Cell 17, 2-.
• Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland In?ammation in a Mouse Model of Sjögren’s Syndrome.(2018)
  Puñet-Ortiz J, Sáez Moya M, Cuenca M, Caleiras E, Lazaro A, Engel P
  Front Inmmunol 9, 2661-.
• Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.(2016)
  Mosteiro LL, Pantoja C, Alcazar N, Marión RM, Chondronasiou D, Rovira M, Fernandez-Marcos PJ, Muñoz-Martin M, Blanco-Aparicio C, Pastor J, Gómez-López G, de Martino A, Blasco MA, Abad M, Serrano M
  Science 354, pii: aaf4445.-0.
• K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.(2016)
  Hernández-Porras I, Schuhmacher AJ, Garcia-Medina R, Jiménez B, Cañamero M, de Martino A, Guerra C
  J Pathol 239, 206-217.
• Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.(2016)
  de Lucas AG, Schuhmacher AJ, Oteo M, Romero E, Cámara JA, de Martino A, Arroyo AG, Morcillo MÁ, Squatrito M, Martinez-Torrecuadrada JL, Mulero F
  PLoS ONE 11, e0158634-.
• Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development.(2015)
  González-Loyola A, Fernández-Miranda G, Trakala M, Partida D, Samejima K, Ogawa H, Cañamero M, de Martino A, Martínez-Ramírez Á, de Cárcer G, Pérez de Castro I, Earnshaw WC, Malumbres M
  Mol Cell Biol 35, 3566-3578.
• Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.(2014)
  Bär C, de Jesus BB, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA.
  Nat Communications 5, 5863-.
• Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRasG12V-driven pancreatic tumourigenesis.(2014)
  Flandez M, Cendrowski J, Cañamero M, Salas A, Del Pozo N, Schoonjans K, Real FX
  Gut 63, 647-655.
• Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.(2014)
  Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, Elling U, Penninger JM
  Nat Genet 46, 1028-1033.
• Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.(2014)
  Arias MA, Jiménez de Bagües MP, Aguiló N, Menao S, Hervás-Stubbs S, de Martino A, Alcaraz A, Simon MM, Froelich CJ, Pardo J
  Cell Reports 8, 420-429.
• MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy.(2014)
  Bobadilla M, Sáinz N, Rodriguez JA, Abizanda G, Orbe J, de Martino A, García Verdugo JM, Páramo JA, Prósper F, Pérez-Ruiz A.
  Stem Cells 32, 447-461.
• Single-walled carbon nanotubes (SWCNTs) enhance KCl-, acetylcholine-, and serotonin-induced contractions and evoke oxidative stress on rabbit ileum.(2014)
  Grasa L, Ansón-Casaos A, Martínez MT, Albendea R, De Martino A, Gonzalo S, Murillo MD
  Journal of Biomed Nanotechnol 10, 529-542.
• Angiogenesis and proliferation markers in adjacent cirrhotic tissue could predict hepatocellular carcinoma outcome after liver transplantation.(2014)
  Campillo A1, Solanas E, Morandeira MJ, Castiella T, Lorente S, Garcia-Gil FA, Piazuelo E, de Martino A, Serrano MT
  Eur J Gastroen Hepat 26, 871-879.
• Solitary tumours associated with Jaagsiekte retrovirus in sheep are heterogeneous and contain cells expressing markers identifying progenitor cells in lung repair.(2014)
  De las Heras M, de Martino A, Borobia M, Ortín A, Álvarez R, Borderías L Giménez-Más JA
  J Comp Pathol 150, 138-147.
• Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade.(2013)
  Martinez-Delgado B, Gallardo M, Tanic M, Yanowsky K, Inglada-Perez L, Barroso A, Rodriguez-Pinilla M, Cañamero M, Blasco MA, Benitez J
  Breast Cancer Res Treat 141, 231-242.
• Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.(2013)
  Narlik-Grassow M, Blanco-Aparicio C, Cecilia Y, Perez M, Muñoz-Galvan S, Cañamero M, Renner O, Carnero A
  PLoS ONE 8, e60277-.
• Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice.(2013)
  Martinelli P, Cañamero M, del Pozo N, Madriles F, Zapata A, Real FX
  Gut 62, 1481-1488.
• The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.(2013)
  Eguren M, Porlan E, Manchado E, García-Higuera I, Cañamero M, Fariñas I, Malumbres M
  Nat Communications 4, 2880-.
• Requirements for aurora-a in tissue regeneration and tumor development in adult mammals.(2013)
  Pérez de Castro I, Aguirre-Portolés C, Fernández-Miranda G, Cañamero M, Cowley DO, Van Dyke T, Malumbres M
  Cancer Res 73, 6804-6815.
• SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.(2013)
  Herranz D, Maraver A, Cañamero M, Gómez-López G, Inglada-Pérez L, Robledo M, Castelblanco E, Matias-Guiu X, Serrano M
  Oncogene 32, 4052-4056.
• Influence of RET mutations on the expression of tyrosine kinases in medullary thyroid carcinoma.(2013)
  Rodríguez-Antona C, Muñoz-Repeto I, Inglada-Pérez L, de Cubas AA, Mancikova V, Cañamero M, Maliszewska A, Gómez A, Letón R, Leandro-García LJ, Comino-Méndez I, Sanchez L, Alvarez-Escolá C, Aller J, Cascón A, Robledo M
  Endocr-Relat Cancer 20, 611-619.
• Programmed Cell Senescence during Mammalian Embryonic Development.(2013)
  Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Cell 155, 1104-1118.
• BCL7A protein expression in normal and malignant lymphoid tissues.(2013)
  Ramos-Medina R, Montes-Moreno S, Maestre L, Cañamero M, Rodríguez-Pinilla M, Martínez-Torrecuadrada JL, Piris MA, Majid A, Dyer MJ, Pulford K, Roncador G
  Br J Haematol 160, 106-109.