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Cancer Research. The CNIO creates a collaborative platform to streamline brain metastasis research

08.07.2020

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Brain metastasis Cancer cells (in green) invading a mouse brain (blood vessels in red). /CNIO

The Brain Metastasis Cell Lines Panel (BrMPanel) is the first to compile information on more than 60 cell lines related to brain metastasis research

The platform was spearheaded by CNIO researcher Manuel Valiente, who coordinated its 19 constituent international laboratories and seeks to turn it into a ‘white paper’ for research in this area

The goal is to streamline brain metastasis research for the development of therapies and to encourage new scientific teams to participate in studying this area, which constitutes one of the main challenges of cancer research

Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result research progresses less quickly. In recent years, largely thanks to the development of the digital ecosystem, these communication barriers are being overcome, which results in improved transparency and knowledge exchange between scientific teams.

In line with this trend, for the first time, a group of 19 international laboratories has agreed to digitally pool and organise their information on brain metastasis, with the aim of facilitating their research and speeding up obtaining results and effective therapies. This effort was coordinated by the Brain Metastasis Group, led by Manuel Valiente at the Spanish National Cancer Research Centre (CNIO), and the information has been integrated into the website of the CNIO Brain Metastasis Cell Lines Panel (BrMPanel). The paper is published in Cancer Research, a journal of the American Association for Cancer Research.

A repository of cell lines…

Between 10 and 30% of all cancer patients develop brain metastases, especially from breast, lung and skin tumours, and cases are on the rise. Two of the main challenges of cancer research lie in understanding why some tumour cells manage to overcome the strong defensive barriers of the brain against metastases and to develop therapies against this phenomenon.

Now, these laboratories (from Germany, China, the United States, Ireland, Israel, the United Kingdom, Norway and Switzerland, and the CNIO representing Spain) have joined forces to assemble in the BrMPanel all information generated on more than 60 cell lines related to their research.

Cell lines, a cornerstone of scientific research, are collections of human or animal cells that have been tailored to grow in the laboratory. They are fundamental in biomedical research since they allow reproducing at the cellular and genetic level what happens in a sick organism, in a way that allows gaining a thorough understanding of the mechanisms that produce the disease and exploring effective therapies for it.

“The platform contains cell lines of all kinds,” explains Manuel Valiente, initiator and coordinator of the initiative, “from cell lines that have been cultivated in vitro for years, through lines developed from mouse models that spontaneously generated brain metastases, to the so-called PDX lines – extracted from a patient and the most genetically similar to that patient.”

… and a ‘white paper ’on how to use them in the most effective way

The BrMPanel also explains how to use these biological materials -since each line requires a different strategy depending on what is being studied-, what therapies have been tried in them, and if they have led to a clinical trial in patients and with what result. “Our goal is to encourage more teams to investigate brain metastasis, by facilitating the first step of finding the best model to work with,” continues Valiente.

The platform has been very well received since its launch, and with its publication now in Cancer Research, the researchers hope that it will become a white paper for brain metastasis research.

Valiente explains that “it is a pity that it is so difficult to obtain such basic information, which leads to situations like a laboratory dedicating for months resources and efforts to develop a cell line that has already been created by somebody else, with all delays in the study this implies. Now, more than ever, we are at a moment that resources must be optimised and we must make everything we know available to other groups to avoid duplication of work that has already been done.”

The researchers also hope that the BrMPanel will grow through contributions from new laboratories, and even that it will inspire other teams to create panels of metastatic cell lines of other organs.

The support of the following funding agencies has made the development and characterisation of some of these research resources possible: The Spanish Ministry of Science and Innovation, the National Institute of Health Carlos III, the Melanoma Research Alliance, The Ramón Areces Foundation, Worldwide Cancer Research, the Cancer Research Institute, The Spanish Association Against Cancer, the Ramón y Cajal Programme and the EMBO YIP Programme.

Reference article

Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Manuel Valiente et al (Cancer Research, 2020). DOI: 10.1158/0008-5472.CAN-20-0291

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