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Researchers have found that these tumours can be classified into two types using the p21 and mTOR markers
The presence of these markers corresponds to a less aggressive evolution of the disease
This could be the basis for more specific treatments depending on the type of cancer
Head and neck cancers are listed sixth in incidence and constitute the eighth leading cause of death by cancer
Section of a head and neck cancer biopsy stained for p21 (brown) and for S6 phosphorylation (red). S6 phosphorylation depends directly on mTOR and, therefore, its detection is an indication of mTOR activity. /CNIO
Reference article
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Susana Llanos, Juana M. García-Pedrero, Lucia Morgado-Palacin, Juan P. Rodrigo, Manuel Serrano. Nature Communications (2016). doi: 10.1038/ncomms10438