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Basic Research

gTuRC Basic Research
Science Advances. Scientists from the CNIO and IRB Barcelona assemble the γ-tubulin ring complex in vitro for the first time Researchers from the Microtubule Organization lab, headed by Jens Lüders at IRB Barcelona, and the...
Islet insulin glucagon, CNIO Basic Research
Cell Reports Medicine. A CNIO team describes how a virus can cause diabetes It has recently been described that infection by some enteroviruses – a genus of viruses that...
Marisol Soengas, David Olmeda, Daniela Cerezo, CNIO Basic Research
Nature Medicine. CNIO research team finds how melanoma deceives the immune system, increasing resistance to immunotherapy The sophisticated human immune system has evolved to become an effective protection system against a...
Video MIDKINE Marisol Soengas Basic Research
How melanoma ‘deceives’ the immune system, increasing resistance to immunotherapy A CNIO research team has found how melanoma ‘deceives’ the immune system, increasing...
Spikebody, CNIO Basic Research
The 12 de Octubre Hospital and the CNIO design a new immunotherapy method for fighting different types of coronaviruses A project to generate antibody responses to Covid-19, carried out at the Immunology Unit of 12 de...
CRISPR and fusion genes Basic Research
Nature Communications. CNIO scientists succeed in reprogramming the CRISPR system in mice to eliminate tumour cells without affecting healthy cells The CRISPR/Cas9 gene-editing tool is one of the most promising approaches to advancing treatments of...
E-caderina and R-caderina in breast cancer Basic Research
CP&T. CNIO researchers identify genetic factors associated with the risk to develop hand-foot syndrome during chemotherapy with capecitabine Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend...
CDK4 and RAF1 inactivation Basic Research
PNAS. CNIO researchers develop an effective strategy to induce regression in lung tumours caused by the KRAS oncogene in mice The KRAS oncogene is involved in at least one fifth of all human cancers: KRAS mutations are...
Wild type and STAG2 knock out murine embryos Basic Research
Cell Reports. CNIO and CNIC researchers find clues to clarify why the protein that ‘embraces’ chromosomes has a role in cancer and cardiac development Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified...