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Basic Research

Mouse senescent epithelial cells, CNIO Basic Research
Developmental Cell. A connection between senescence and stem cells caused by a breast cancer-initiating protein Early diagnosis and improvement of breast cancer treatments have reduced breast cancer mortality in...
Mouse motor neurons, CNIO Basic Research
The EMBO Journal. CNIO researchers discover the cause of neuronal death in a large proportion of familial ALS patients In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement...
Mouse adipocytes Basic Research
Nature Metabolism. CNIO researchers discover that a drug already in use in humans corrects obesity in mice, with no side effects It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of...
TOP2A and DNA Basic Research
Cell Reports. DNA structure itself is involved in genome regulation, scientists find The (when stretched) two-metre-long DNA molecule in each human cell is continuously being unpacked...
DNA and MutS Basic Research
Nature Structural & Molecular Biology. An international study reveals how the ‘guardian’ of the genome works Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at...
Embryonic stem cells, CNIO Basic Research
Nature Communications. CNIO researchers describe how embryonic stem cells maintain optimal conditions for use in regenerative medicine Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed...
Sarita Saraswati, Paula Martínez and Maria A. Blasco Basic Research
Nature Aging. CNIO researchers open the door to treatment of renal fibrosis by showing that it is caused by telomere shortening Ageing is a common factor in many diseases. So, what if it were possible to treat them by acting on...
TRF1 and telomeres Basic Research
PLOS Genetics. A CNIO team discovers how telomere involvement in tumour generation is regulated The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research...
Long and short telomeres Basic Research
Aging. A CNIO study links severe COVID-19 disease to short telomeres Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study...