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Basic Research

SolipPark-Figure-V1 Basic Research
Nature Communications. One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer The language in which the genome’s book of life is written is still being deciphered, which is...
Structure of the LAT2/CD98hc protein Basic Research
PNAS. Spanish scientists determine the mode of action of essential proteins involved in cancer and Alzheimer´s disease The proteins that belong to the HAT family are essential for life as they transport amino acids...
Basic Research
eLife. A master regulator gene for brain cancer with the worst prognosis Researchers at the CNIO and scientists from the School of Medicine of the University of Fribourg,...
Tumor pulmonar inducido por el KRAS4A. /CNIO Basic Research
PNAS. CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in human cancer KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common...
Alejo Efeyan and Ana Ortega, CNIO Basic Research
Cell Reports. CNIO researchers discover a new pathway to tackle follicular lymphoma For their own benefit and to grow beyond control, tumours manipulate cell signals to make it appear...
Estructura TELO2-TTI1-TTI2 complejo mTOR Basic Research
Cell Reports. CNIO researchers help to decipher the structure of the large molecular machine that assembles and activates mTOR The principle that form follows function does not only apply to design and architecture. It also...
De izquierda a derecha: Ana Belén-Plata Gómez, Alejo Efeyan y Nerea Deleyto-Seldas. /CNIO Basic Research
Nature Communications. A molecular switch that allows organisms to adapt to fasting conditions Getting energy and nutrients from the environment – that is, eating – is such an important...
PrimPol binds to damaged DNA Basic Research
The EMBO Journal. A protein that facilitates DNA repair may potentiate chemotherapy Chemotherapy kills tumour cells by causing damage to them. One of the most effective ways of causing...
T7SS secretion system of 'M. tuberculosis' Basic Research
Nature Reviews Microbiology. An international team reviews the latest advances in the understanding of the molecular mechanisms of tuberculosis Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, a bacterium that usually...