Home > About Us > CNIO Publications

CNIO Publications

Liver progenitor cells

Cell Reports

Liver progenitor cells are involved in the development of hepatic tumours

Madrid, 18 April, 2017

The malignant transformation of hepatocytes is the origin of most hepatocellular carcinomas, an aggressive type of liver cancer with high mortality rates. But these cells do not act alone. Research conducted by scientists at the Spanish National Cancer Research Centre (CNIO) reveals how hepatocytes "recruit" and "instruct" liver progenitor cells to contribute to the hepatic lesions."The cellular origin of liver cancer, as well as the origin of tumour heterogeneity, are not clear yet and may be...

Read more...
c-Fos expressing pre-malignant mouse hepatocytes

The Journal of Experimental Medicine

A novel molecular link between cholesterol, inflammation and liver cancer

Madrid, 29 March, 2017

Hepatocellular carcinoma (HCC) is a deadly disease with no effective cure that develops in the context of liver diseases associated with chronic inflammation. A recent research article published in The Journal of Experimental Medicine describes how important a protein called c-Fos is for HCC development, because it affects cholesterol homeostasis in hepatocytes, the main cells of the liver. Using genetically modified mouse models (GEMMs), Erwin Wagner, director of the Cancer Cell Biology...

Read more...
Células metastásicas de cáncer de mama (en rojo) anidando en nichos metastásicos en el pulmón.

Nature Reviews

Tighten the grip on metastasis

Madrid, 17 March, 2017

Metastasis is the major cause of cancer-related death and its appearance remains a phenomenon that is difficult to predict and manage. We now know that, prior to the arrival of the cancer cells, tumours prepare the ground in the organ that they will later colonise. These areas with ideal conditions for the onset of metastasis are called pre-metastatic niches and targeting them will help improve patient survival. These questions are the subject of a review paper published in Nature Reviews by an...

Read more...

Stem Cell Reports

'In vivo’ reprogramming induces signs of telomere rejuvenation

Madrid, 2 February, 2017

During the 'in vivo’ reprogramming process, cellular telomeres are extended due to an increase in endogenous telomerase. This is the main conclusion of a paper published in 'Stem Cell Reports' by a team from the Spanish National Cancer Research Centre (CNIO). Their observations show, for the first time, that the reprogramming of living tissue results in telomerase activation and telomere elongation; thus reversing one of the hallmarks of aging: ‘the presence of short telomeres’. "We have...

Read more...
Imagen de la enzima oxidoreductasa

PNAS

Secrets of human protein interactions unveiled by massive sequencing and coevolution

Madrid, 15 December, 2016

Cells operate like an incredibly well-synchronized orchestra of molecular interactions among proteins. Understanding this molecular network is essential not only to understand how an organism works but also to determine the molecular mechanisms responsible for a multitude of diseases. In fact, it has been observed that protein interacting regions are preferentially mutated in tumours. The investigation of many of these interactions is challenging. However, a study coordinated by Simone Marsili...

Read more...
El daño tisular es clave para la reprogramación celular

Science

Tissue damage is key for cell reprogramming

Madrid, 24 November, 2016

Cell reprogramming does not happen exactly as we thought. In the pages of the journal Science, a team from the Spanish National Cancer Research Centre (CNIO) has shown that tissue damage is a relevant factor for cells to go back to an embryonic state. Cell reprogramming earned its discoverer, Shinya Yamanaka, the Nobel Prize and opened the door to regenerative medicine. This technique, based on introducing a combination of four genes known as OSKM (for the initials of the genes, OCT4,...

Read more...
CPEB4 es clave para la supervivencia de las células del melanoma

Nature Communications

A protein that defines the melanoma blueprint

Madrid, 18 November, 2016

The main goals of the Melanoma Group at the Spanish National Cancer Research Centre (CNIO) are to identify biomarkers of tumour progression and to validate novel therapeutic targets in melanoma. In particular, their research focuses on discovering features that define the "fingerprint" of this tumour, features that distinguish it from other cancer types. The latest study in this area, published in Nature Communications, describes the roles of CPEB4; a protein that is crucial for melanoma cell...

Read more...
Parte del equipo del CNIO que ha participado en el proyecto BLUEPRINT

Cell Press

The CNIO takes part in the biggest european project for the study of the epigenome

Madrid, 17 November, 2016

The International Human Epigenome Consortium (IHEC) publishes simultaneously a collection of 41 papers that contain major advances in the study of the human epigenome - 24 of which appear today in Cell Press magazines. The Structural Biology and Biocomputing Programme together with the National Bioinformatics Institute Unit at the Spanish National Cancer Research Center (CNIO) participated in several studies, leading three of them. One of the great mysteries in biology is how the many...

Read more...
Laboratorio de Epigenética CNIO-Lilly

Scientific Reports

CNIO and Eli Lilly and Company identifie a new therapeutic target for lung cancer

Madrid, 10 October, 2016

Cancer is a different disease in each patient, and improved treatment demands knowing more about the personal characteristics of each tumor. A CNIO team has discovered a new alteration in lung cancer, and thus a new therapeutic target to develop specific drugs. The finding is therefore a step towards customizing the treatment of lung cancer.The work, published today in the journal Scientific Reports, has been possible thanks to the collaboration of the CNIO with Lilly.The reported alteration...

Read more...
Piruvato quinasa

Trends in Biochemical Sciences

Scientists at the CNIO have deconstructed one of the myths of biological innovation

Madrid, 3 October, 2016

While the number of coding genes (those that produce proteins) in the human species has been consistently dwindling in recent years - the figures have fallen to fewer than 20,000-, it has been claimed that the dimension of the proteome, the element that executes the instructions in the genome, could be larger. This diversity of proteins has become one of the main sources of complexity in mammals, including the human species. This theory could have an expiry date according to a study headed...

Read more...