Centro Nacional de Investigaciones Oncológicas (Spanish National Cancer Research Centre)

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Home > National Health System Support Services: Familial Cancer

• Request Form (110 KB)
• Presentation
• Familial Cancer Consultancy
• Hereditary and Familial Cancer
• Appendix 1
  • a. Entities with autosomal dominant inherintance, in which the genetic analysis affects the clinical management
  • b. Entities with autosomal dominant inheritance, in which the genetic analysis has potential clinical value
  • c. Entities with autosomal recessive inheritance
  • d. Other entities with predisposition to cancer

d. Other entities with predisposition to cancer

Pathology	Incidence	Gene	Locus
Esophageal cancer with palmoplantar tylosis	Unknown	-	-
Familial gastric cancer	Unknown	CDH1	16q22.1
Familial nonmedullary thyroid carcinoma	Unknown	-	-
Familial prostate carcinoma	Unknown	-	-
Familial renal cell carcinoma (clear cell)	Unknown	-	3p?
Familial papillary renal carcinoma	Unknown	MET	7q31
Carney complex	Rare	PRKRA1A	17q23-q24
Congenital dyskeratosis	Unknown	DKC1	Xq28
X-linked lymphoproliferative Syndrome or Duncan disease	Rare	SH2D1A	Xq25
Sotos Syndrome	Rare	NSD1	5q35

In these families, the descendants of a carrier of the mutation have a 50% probability of inheriting the altered gene; whether they will develop cancer during their lifetime depends on whether the inheritance follows a dominant or a recessive model.