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Cancer Cell Biology Programme

Seve-Ballesteros Foundation Brain Tumour Group

Group Leader:  Massimo Squatrito
Overview

Malignant gliomas (astrocytomas, oligodendrogliomas and oligoastrocytomas) are the most frequent form of brain tumours and Glioblastoma Multiforme (GBM), a grade IV astrocytoma, is the most lethal tumour of the central nervous system in the adult. Standard GBM therapy consists of tumour resection and postsurgical treatment with chemotherapy and ionising radiation (IR). Although there have been improvements in surgical and imaging techniques, available treatments for GBMs are still inefficient, most likely due to intrinsic resistance to the current therapeutic modalities and high cellular heterogeneity.

In our laboratory, we use a combination of genomic analysis, mouse models and primary tumour cell cultures, with the main goal of identifying the molecular mechanisms that could provide the basis for novel treatments for GBM patients.