Biotechnology Programme

Proteomics Core Unit

Head of Unit:  Javier Muñoz
Overview

Proteins catalyse and control almost all cellular processes in a living cell. The levels of protein abundance, together with their modification states and interactions, adapt dynamically to external or internal (genetic) stimuli and thus define the cell’s functional state and determine its phenotype. Recent developments in sample preparation, liquid chromatography, mass spectrometry and data analysis have enabled researchers to investigate diverse proteomic facets in a systematic highthroughput manner, currently comparable to next-generation sequencing platforms. As a result, proteomics is positioned as one of the most powerful technologies to study, at the protein level, complex cellular processes. This vast amount of data is providing new insights into the molecular mechanisms underlying diverse human pathologies such as cancer.