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Structural Biology Programme

Structural Bases of Genome Integrity Group

Group Leader:  vacancy
Overview

Safeguarding genome integrity is essential for correct cell functioning and to prevent cancer. Our Group is interested in understanding central cellular processes that affect the integrity of the genome, such as the metabolism of nucleotides, DNA recombination or the maintenance and recognition of chromatin architecture. These processes depend on the assembly of large and dynamic macromolecular complexes. We combine protein engineering, X-ray crystallography, nuclear magnetic resonance (NMR) and single-particle electron microscopy (EM), together with biochemical and functional studies, in order to decipher the structure of these protein-protein and protein-DNA complexes, as well as to understand their catalysis and regulatory mechanisms at the atomic level. This knowledge should guide the design of compounds to modulate protein activity and provide novel opportunities for fighting tumours.