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Cancer Cell Biology Programme

Growth Factors, Nutrients and Cancer Group

Group Leader:  Nabil Djouder
Overview

The incidence of metabolic disease and cancer has increased to epidemic proportions, possibly due to hypernutrition and a more sedentary life style with less energy expenditure. Our laboratory studies the molecular mechanisms of disease associated with the deregulation of growth factor and nutrient signalling pathways. Identifying new components of the growth factor and nutrient cascades, as well as elucidating their role and functions in vivo by generating new genetically engineered mouse models (GEMMs), will help us to better understand how nutrient overload can induce metabolic disorders and cancer.

Thus, using cell biological and biochemical techniques, combined with in vivo mouse models and human data, our lab devotes efforts to the development of innovative mechanism-based therapeutics to potentially treat metabolic dysfunctions and cancer.

Research concepts from our laboratory
  • Metabolic alterations initiate tumorigenesis prior to genomic instability.
  • Inhibition of de novo NAD+ synthesis functions a non-oncogene addiction pathway in liver and pancreas cancer.
  • Oncogene-induced NAD+ depletion in DNA damage.