Scientific Programmes

Structural Biology and Biocomputing Programme

Structural Computational Biology Group

Group Leader:  Alfonso Valencia

The main interest of our group is the study of the molecular bases of cancer progression. We bring an evolutionary perspective to the study of the interplay between genomics and epigenomics in tumour progression.

Our research is largely carried out in the context of large-scale genome projects, where we develop computational methods in order to reveal the general properties of the genome-cancer relationships, via analysis of high-throughput datasets.

In this framework, the strategic goals of the Structural Computational Biology Group are to:

  • Develop software platforms for the extraction, integration and representation of cancer data – including the statistical analysis of molecular, genomic, epigenomic and phenotypic information – in collaboration with large-scale genome projects.
  • Analyse the function, structure and specific interactions of cancer- related proteins.
  • Develop methods, tools and ideas to understand and model processes relating to genome structure, organisation and evolution, with a special focus on tumour progression.