Tumour suppressors are genes that can prevent the development of cancer. All our cells have a functional set of these genes. However, despite their efficient protection against cancer, these genes can become defective over time. The affected cells thus become partially unprotected from cancer and, in combination with additional mutations in other genes, can give rise to the development of cancer.
Understanding how tumour suppressor genes work may help us to design drugs that block cancer. Our Group also manipulates the mouse genome to create novel alterations that increase or decrease tumour suppression potency.