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María José Bueno

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Clinical Research Programme

Breast Cancer Clinical Research Unit

Biosketch: María José Bueno

María José Bueno Verdejo was born in 1980, in Madrid (Spain). She got her degree in Biology in 2003 from the Universidad Complutense de Madrid (UCM) after a two-years undergraduate training (2001-2003) in the Departments of Genetics and Microbiology under the supervision of Dra.  Mª Teresa González and  Dra. Covadonga Vázquez. During this period of time she focused on the Characterization and in vitro expression patterns of an exopolygalacturonase encoding gene from Fusarium oxysporum.

In 2004 she moved to the laboratory of Dr. Fernández Piqueras at the Universidad Autónoma de Madrid, where she obtained her PhD in Cancer and Cellular Biology in 2008. Her research focused on the characterization of genetic and epigenetic alterations in the origin and development of T-cell lymphomas using a mouse model system.  During her PhD studies she identified a novel microRNA (miRNA), miR-203, involved in the development of some specific hematopoietic malignancies.

From 2008 to 2011 she was a postdoctoral fellow in Dr. Marcos Malumbres’ laboratory at the CNIO. There, she expanded her work on the study of miR-203 and its possible role as tumor suppressor gene using mouse models and on the other hand she studied the relevance of microRNAs in the cell cycle at different levels.  She first analyzed the expression of miRNAs in early cell cycle phases and identified several clusters of miRNAs that are induced by E2F transcription factors during the early phases of the cell cycle. Several of these miRNAs modulate major proliferation pathways by controlling the expression of critical cell cycle regulators such as cyclins and cyclin-dependent kinases.

In February 2012 she joined to the Breast Cancer Clinical Unit.

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