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Scientific Programmes

Molecular Oncology Programme

Metabolism and Cell Signaling Group

Group Leader:  Alejo Efeyan
Overview

In the Metabolism and Cell Signalling Lab, we study the interplay between nutrients, metabolism and cancer. The alarming increase of overweight and obesity over the last decades and the epidemiological links between elevated nutrient levels and human disease calls for a better understanding of the molecular underpinnings of these connections. Conversely, limiting nutrient intake to an extent that does not cause malnutrition is not only protective against diabetes, but also prevents cancer development and delays ageing in most multicellular species by mechanisms that are poorly understood. In the lab, we combine mouse genetics and cell biological tools to gain insight into the cellular processes that become corrupted upon nutrient overabundance, aiming to conceive therapeutic interventions targeting these processes in the context of cancer and the process of ageing.